The Application of Transition Radiation to Non-invasive Angiography (Physics)

过渡辐射在无创血管造影中的应用（物理）

• 批准号: 8521270
• 负责人: Melvin Piestrup
• 金额: $ 22.44万
• 依托单位: Adelphi Technology, Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1990-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8521270&HistoricalAwards=false
• 关键词: Application; Transition; Radiation; Non; invasive

The purpose of this research is to demonstrate the value of transition radiation in angiography. Within this area of diagnostic radiology, the specific interest is centered on the development of a non-invasive method of coronary angiography based on the use of monoenergetic x-rays at energies close to the K-absorption edge of iodine. In the past, both conventional and synchrotron sources have been used. Unfortunately, the conventional sources lack monochromatic x- ray beams of adequate intensity, while the cost of a synchrotron source is prohibitive. The specific motivation for the proposed studies is an urgent need to reduce both the risk and cost of coronary arteriography. The proposed method involves the acquisition of radiographs at x-ray energies slightly above and below the k-edge in iodine at 33.16 keV and the subsequent digital subtract of these two images to achieve maximum contrast in the visualization of the intra-arterial iodine. The high brightness and laser-like collimation of transition radiation make it an ideal source of x-rays for medical applications. This source has received a relatively small amount of attention as a x-ray generator of high brightness. Yet the radiation per electron is several orders of magnitude greater than synchrotron radiation, and, as demonstrated in Phase I of this program, a moderate electron beam of 100 to 500 MeV can be used, whereas a synchrotron source requires electron energies of 3 GeV or greater to obtain 30 keV photons. Transition radiation is a cost effective source of hard x- rays for non-invasive angiography for the detection of coronary disease; lithography for the production of integrated circuits; x-ray analysis of biological material; and high resolution medical x-ray of organs such as kidneys and heart.

这项研究的目的是证明价值 血管造影术中的过渡辐射。 在这一领域内， 诊断放射学，具体的兴趣是集中在 无创冠状动脉造影方法的发展 基于使用能量接近 碘的K吸收边。 在过去，两者 已经使用了常规和同步加速器源。 不幸的是，传统的光源缺乏单色X-射线。 射线束足够的强度，而成本的一个 同步辐射源是禁止的。 具体动机为 建议的研究是迫切需要减少风险， 和冠状动脉造影的费用。 该方法 涉及在X射线能量下获取射线照片 略高于和低于碘在33.16 keV的k边缘， 随后对这两个图像进行数字相减以实现 动脉内可视化的最大对比度 碘。 的高亮度和类似激光的准直 过渡辐射使其成为理想的X射线源， 医疗应用。 这一消息来源得到了相对 少量的注意力作为高X射线发生器 亮度松开 然而每个电子的辐射是几个数量级 的幅度大于同步辐射，而且，作为 在这个项目的第一阶段，一个中等的电子 可以使用100至500 MeV的光束，而同步加速器 源需要3 GeV或更大的电子能量来获得 30千电子伏光子。 过渡辐射是硬x射线的一种成本有效的来源， 用于检测冠状动脉的非侵入性血管造影的X射线 疾病;用于生产集成电路的光刻技术; 生物材料的X射线分析;以及高分辨率 对肾脏和心脏等器官进行的医学x光检查。