PCSK9: Functions and mechanisms of action in liver and adipocytes

PCSK9：肝脏和脂肪细胞的功能和作用机制

• 批准号: 188345
• 负责人: Seidah Nabil G
• 金额: $ 57.98万
• 依托单位: Institut de recherches cliniques de Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-09-01 至 2014-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=188345&lang=en
• 关键词: Cell Biology; Cholesterol And Fatty Acids; Mechanisms And Physiology; Mouse Knockout And Transgenic Models; Proteases; Stucture-Function

Our group has been at the forefront of discovering and characterizing a family of enzymes known as the proprotein convertases and in unraveling their role in normal biology and in human disease. In this application we propose to continue this line of rese

我们的团队一直处于发现和表征一个被称为前蛋白转化酶的酶家族的最前沿，并揭示了它们在正常生物学和人类疾病中的作用。在本申请中，我们建议继续这一路线的研究。