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PCSK9: Functions and mechanisms of action in liver and adipocytes

PCSK9: Functions and mechanisms of action in liver and adipocytes
PCSK9：肝脏和脂肪细胞的功能和作用机制
批准号：
188345
负责人：
Seidah Nabil G
金额：
$57.98万
依托单位：
Institut de recherches cliniques de Montral
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-09-01 至 2014-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=188345&lang=en
关键词：
Cell Biology Cholesterol And Fatty Acids Mechanisms And Physiology Mouse Knockout And Transgenic Models Proteases Stucture-Function

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中文摘要
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英文摘要
Our group has been at the forefront of discovering and characterizing a family of enzymes known as the proprotein convertases and in unraveling their role in normal biology and in human disease. In this application we propose to continue this line of rese
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The unique and complementary functions of PCSK7 and PCSK9 in cardiometabolic health and disease
CRC Tier 1
  • 批准号：
    364795
  • 项目类别：
  • 资助金额：
    $101.99万
  • 财政年份：
    2016
  • 负责人：
    Seidah Nabil G
  • 依托单位：
    Universit de Montral
The proprotein convertases and their partners in health and disease
The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance
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