How does substrate cleavage by the proprotein convertases impact on physiology and pathology?

前蛋白转化酶的底物裂解如何影响生理学和病理学？

• 批准号: 265386
• 负责人: Seidah Nabil G
• 金额: $ 7.29万
• 依托单位: Institut de recherches cliniques de Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-04-01 至 2013-04-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=265386&lang=en
• 关键词: Cellular Growth And Extracellular Matrix; Enzymology And Biochemistry; Furin; Knockout Mice; Molecular And Cell Biology; Mutagenesis; Neuroendocrine Functions Of Anxiety And Depression; Pace4 And Pc7; Physiology And Biosynthesis; Proprotein Convertases Pc

We are at the forefront of the discovery and characterization of the proprotein convertases (PCs), a family of mammalian proteases involved in the activation of a wide variety of precursors, a crucial regulatory process in both normal & disease states. In

我们处于前蛋白转化酶（PC）的发现和表征的最前沿，这是一个哺乳动物蛋白酶家族，参与各种前体的激活，这是正常和疾病状态下的关键调节过程。在