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How does substrate cleavage by the proprotein convertases impact on physiology and pathology?

How does substrate cleavage by the proprotein convertases impact on physiology and pathology?
前蛋白转化酶的底物裂解如何影响生理学和病理学？
批准号：
265386
负责人：
Seidah Nabil G
金额：
$7.29万
依托单位：
Institut de recherches cliniques de Montral
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-04-01 至 2013-04-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=265386&lang=en
关键词：
Cellular Growth And Extracellular Matrix Enzymology And Biochemistry Furin Knockout Mice Molecular And Cell Biology Mutagenesis Neuroendocrine Functions Of Anxiety And Depression Pace4 And Pc7 Physiology And Biosynthesis Proprotein Convertases Pc

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英文摘要
We are at the forefront of the discovery and characterization of the proprotein convertases (PCs), a family of mammalian proteases involved in the activation of a wide variety of precursors, a crucial regulatory process in both normal & disease states. In
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The unique and complementary functions of PCSK7 and PCSK9 in cardiometabolic health and disease
CRC Tier 1
  • 批准号：
    364795
  • 项目类别：
  • 资助金额：
    $101.99万
  • 财政年份：
    2016
  • 负责人：
    Seidah Nabil G
  • 依托单位：
    Universit de Montral
The proprotein convertases and their partners in health and disease
The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance