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The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance

The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance
PCSK9 活性缺失时 LDLR 的性别/组织特异性调节及其临床相关性
批准号：
339847
负责人：
Seidah Nabil G
金额：
$10.93万
依托单位：
Institut de recherches cliniques de Montral
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2015
资助国家：
加拿大
项目状态：
已结题
起止时间：
2015-11-01 至 2017-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=339847&lang=en
关键词：
Enzymology & Biochemistry Females Versus Males Gene Expression & Regulation Genetically Modified Mice Hypercholesterolemia/Inflammation Inflammation Ldl & Ldlr Lipoprotein Metabolism & Atherosclerosis Molecular & Cellular Biology Of Ldlr E2-Regula

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中文摘要
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英文摘要
We discovered a family of 9 enzymes, the proprotein convertases (PCs), which are involved in producing the final forms of active proteins, and are world leaders in understanding their roles in pathologies, especially that of PCSK9 in cardiovascular diseas
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The unique and complementary functions of PCSK7 and PCSK9 in cardiometabolic health and disease
CRC Tier 1
  • 批准号：
    364795
  • 项目类别：
  • 资助金额：
    $101.99万
  • 财政年份：
    2016
  • 负责人：
    Seidah Nabil G
  • 依托单位：
    Universit de Montral
The proprotein convertases and their partners in health and disease
How does substrate cleavage by the proprotein convertases impact on physiology and pathology?
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