The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance

PCSK9 活性缺失时 LDLR 的性别/组织特异性调节及其临床相关性

• 批准号: 339847
• 负责人: Seidah Nabil G
• 金额: $ 10.93万
• 依托单位: Institut de recherches cliniques de Montral
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-11-01 至 2017-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=339847&lang=en
• 关键词: Enzymology & Biochemistry; Females Versus Males; Gene Expression & Regulation; Genetically Modified Mice; Hypercholesterolemia/Inflammation; Inflammation; Ldl & Ldlr; Lipoprotein Metabolism & Atherosclerosis; Molecular & Cellular Biology Of Ldlr E2-Regula

We discovered a family of 9 enzymes, the proprotein convertases (PCs), which are involved in producing the final forms of active proteins, and are world leaders in understanding their roles in pathologies, especially that of PCSK9 in cardiovascular diseas

我们发现了一个由9种酶组成的家族，即前蛋白转化酶（PC），它们参与产生活性蛋白的最终形式，并且在了解它们在病理学中的作用方面处于世界领先地位，特别是PCSK 9在心血管疾病中的作用。