An Analysis of Ethical Concerns Occasioned by the Use of Animals in Exemplary Scientific Research: Diabetes as a Case Study

典型科学研究中使用动物引起的伦理问题分析：以糖尿病为例

• 批准号: 8711362
• 负责人: James Nelson
• 金额: $ 3.59万
• 依托单位: Saint John's University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-10-01 至 1990-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8711362&HistoricalAwards=false
• 关键词: Analysis; Ethical; Concerns; Occasioned; Use

A philosopher specializing in biomedical ethics and a biologist who directs a research laboratory in which research on diabetes is undertaken will study moral problems in the use of animals in scientific research which (a) targets widespread, debilitating diseases, (b) has a record of contributing to the understanding and management of the disease, and (c) operates according to professionally accepted humane standards. Much of the research on diabetes mellitus satisfies these conditions. Through a survey of current diabetological literature, the investigators will determine the patterns of usage of animal models in this research, and relate this to the outstanding questions investigators are currently pursuing. Using techniques of ethical analysis, they will attempt to identify the moral issues suggested by this use of animals and outline different strategies for responding to these questions -- from abolition of the research, through various proposals for replacement, reduction, and refinement of animal use, to intensification of current efforts. They will display the implications of these strategies and assess which courses of action are the most defensible. Preliminary results will be sent for comment to outside experts and consultants. Project results will include presentations, papers and a monograph, and will be made available to a wide audience of interested persons and organizations. This project should make a timely, scholarly contribution to the professional and public discussion of issues surrounding uses of animals in research. The investigators are very well-qualified; institutional support is very good and costs, very reasonable. This is a good example of the kind of cross-disciplinary research EVS should encourage. Total support in the amount of $35,939 is recommended. Of that amount, half comes from the National Institutes of Health and is to be awarded this year. The remainder will be awarded next fiscal year.

一位专门从事生物医学伦理学的哲学家和一位负责糖尿病研究实验室的生物学家将研究在科学研究中使用动物的道德问题，这些科学研究（a）针对广泛的、使人衰弱的疾病，（b）有为理解和管理疾病做出贡献的记录，以及（c）根据专业公认的人道标准进行运作。 许多关于糖尿病的研究都满足这些条件。 通过对当前糖尿病学文献的调查，研究人员将确定本研究中动物模型的使用模式，并将其与研究人员目前正在研究的突出问题联系起来。 他们将利用伦理分析技术，尝试识别这种动物使用所暗示的道德问题，并概述回应这些问题的不同策略——从废除研究，到替代、减少和改进动物使用的各种建议，再到强化当前的努力。 他们将展示这些策略的影响，并评估哪些行动方案最合理。 初步结果将发送给外部专家和顾问征求意见。 项目成果将包括演示文稿、论文和专着，并将提供给感兴趣的个人和组织的广大受众。 该项目应该为围绕研究中动物使用问题的专业和公众讨论做出及时的学术贡献。 调查人员资质非常好； 机构支持非常好，费用也非常合理。这是 EVS 应该鼓励的跨学科研究的一个很好的例子。 建议总支持金额为 35,939 美元。 其中一半来自美国国立卫生研究院，将于今年颁发。 其余部分将在下一财年发放。