Heterocalixrenes (Chemistry)

这项研究得到了有机化学和大分子化学项目的支持。生命系统所利用的分子经过了数十亿年的进化。因此，卟啉和科林家族的结构对维生素B-12、细胞色素C-450、血红蛋白和叶绿素等的催化性能至关重要。这项研究将着眼于一种结构类型，它将允许其中一些系统被模仿。这项研究将合成吡啶类似物的卟啉体系，其中吡咯环将系统地被吡啶官能团取代。这将导致具有贫电子环的四齿大环应该具有许多新的电子和配位性质。我们还将研究相应的三齿系的性质。这项工作应1)开发进入这些体系的新的合成途径；2)“介观”桥的化学修饰；3)这些体系的物理性质的研究；4)金属络合物及其可能的堆积作用的研究。

This research is being supported by the Organic and Macro- molecular Chemistry Program. The molecules utilized by living systems have evolved over billions of years. Thus the porphyrin and corrin families of structures are crucial to the catalytic properties in vitamin B-12, cytochrome C-450, hemoglobin and chlorophyll among others. This research will look into a structural type which will permit some of these systems to be mimicked. This research will synthesize the pyridino analog of the porphyrin system in which the pyrrole rings will be systematically replaced by the pyridino functionality. This will result in quadridentate macrocycles possessing electron- poor rings which should have many novel electronic and coordination properties. The properties of the corresponding tridentate systems will also be examined. The work should 1) develop new synthetic paths into these systems; 2) chemical modification of the "meso" bridges; 3) studies of the physical properties of these systems; and 4) study of the metal complexes and their possible stacking interactions.