Spherical Hydrophilic Polymers: Synthesis, Characterization and Applications

9622609 Newkome本研究的首要主题涉及内部修饰的树枝状聚合物（级联大分子）的制备、结构方面和化学性质的研究。 根据这一目标，设计和合成具有掩蔽的或惰性的可转化官能团的面向应用的树枝状结构单元，以在树枝状聚合物构建后使用。 项目目标包括：1）构建功能分化的树枝状结构单元，用于将面向应用的功能性位点特异性并入树枝状聚合物中。 2)构建具有能够与其他树枝状聚合物形成连接的区室化部分的树枝状聚合物。 3)多个树突状组装体（树突状文库）的同时（“组合”）构建。 4)单分子胶束约束和模板制备单分散、小颗粒、半导体微晶（也称为“量子点”）。 5)将半导体微晶精确排列成三维超阵列，允许Q粒子电子耦合“微调”。 这项研究的优点依赖于与高度支化的、专门设计的大分子的物理化学性质相关的化学研究，以及这些性质所固有的附带效用。 这项研究的结果将扩大基础的理解发生在“设计师”的反应环境中的化学现象。 ***

9622609 Newkome The overriding theme of this research concerns the investigation of the preparation, structural aspects, and chemical properties of dendrimers (cascade macromolecules) that have been internally modified. Pursuant to this goal is the design and synthesis of application-oriented dendritic building blocks possessing masked, or inert, transformable functionality to be accessed for use after dendrimer construction. Project goals include: 1) Construction of functionally differentiated dendritic building blocks for the site-specific incorporation of application-oriented functionality into dendrimers. 2) Construction of dendrimers with compartmentalized moieties capable of forming connections with other dendrimers. 3) Concommitant (`combinatorial") construction of multiple, dendritic assemblies (dendritic libraries). 4) Unimolecular micellar constrained and templated preparation of monodisperse, small particle, semiconductor crystallites (also described as "quantum dots"). 5) Precise arrangement of semiconductor crystallites into three-dimensional superarrays allowing Q-particle electronic coupling "fine tuning". %%% The merits of this research rely on the study of the chemistry associated with physicochemical properties of highly branched, specifically designed, macromolecules, and the attendant utility inherent in those properties. Results of this research will expand foundations for understanding of chemical phenomena occurring within "designer" reaction environments. ***