Spherical Hydrophilic Polymers: Synthesis, Characterization,& Applications

基于数学级数在有机合成中的应用，一系列具有特定尺寸和形状的多向级联聚合物（“树酚”）正在被构建。这些分子具有明确的拓扑结构，在一个完全或几乎不可接近的核心上有一个多功能化的表面。该研究将强调使用不同的中心核心分子、构建块（分支分子）的组合和不同的末端基团来合成和表征各种级联聚合物。通过改变这些末端基团来修饰表面，以确保在一定范围内的溶解度和物理化学性质。这类聚合物的这些物理和化学性质将通过13c核磁共振波谱、电子显微镜、光散射、荧光探针方法、溶解度、渗透压、电导率和质谱的组合来表征。这些特别设计的聚合物的形状将被详细研究，以确定导致它们聚集成胶束的参数。这些单分子胶束的共价连接成超分子级联（“超级木酚”）将产生具有与母体木酚类似形状的大胶束分子，但在分子维度上是宏观的。将继续使用这些级联聚合物作为增溶剂、相转移催化剂、溶解剂和微胶囊化剂。

Based upon the application of mathematical progressions to organic synthesis, a series of multi-directional cascade polymers ("arborols") with specific size and shape are being constructed. These molecules have a defined topology with a polyfunctionalized surface over a totally, or nearly so, inaccessible core. The research will emphasize the synthesis and characterization of a variety of cascade polymers using different central core molecules,combinations(s) of building blocks (branching molecules), and diverse terminal groups. The surface will be modified by changing these terminal groups to ensure a side range of solubilites and physicochemical properties. These physical and chemical properties of this class of polymer will be characterized by a combination of 13 C NMR spectroscopy, electron microscopy, light-scattering, fluorescent-probe methods, solubility, osmotic pressure, conductivity, and mass spectroscopy. The shape of these specifically designed polymers will be studied in detail to determine the parameters that cause their aggregation into micellar assemblies. The covalent linking of these unimolecular micelles into supramolecular cascades ("superaborols") will give rise to the construcation of large micellar molecules possessing shapes analogous to the parent arborol, but macroscipic in molecular dimensions. The use of these (supra)cascade polymers, as solubilizing agents, phase- transfer catalysis, resolving agents, and microencapsulation agents, will be continued.