Spherical Hydrophilic Polymers: Synthesis, Characterization,& Applications

球形亲水聚合物：合成、表征、

• 批准号: 8906792
• 负责人: George Newkome
• 金额: $ 26.01万
• 依托单位: University of South Florida
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-01-01 至 1993-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8906792&HistoricalAwards=false
• 关键词: Spherical; Hydrophilic; Polymers; Synthesis; Characterization

Based upon the application of mathematical progressions to organic synthesis, a series of multi-directional cascade polymers ("arborols") with specific size and shape are being constructed. These molecules have a defined topology with a polyfunctionalized surface over a totally, or nearly so, inaccessible core. The research will emphasize the synthesis and characterization of a variety of cascade polymers using different central core molecules,combinations(s) of building blocks (branching molecules), and diverse terminal groups. The surface will be modified by changing these terminal groups to ensure a side range of solubilites and physicochemical properties. These physical and chemical properties of this class of polymer will be characterized by a combination of 13 C NMR spectroscopy, electron microscopy, light-scattering, fluorescent-probe methods, solubility, osmotic pressure, conductivity, and mass spectroscopy. The shape of these specifically designed polymers will be studied in detail to determine the parameters that cause their aggregation into micellar assemblies. The covalent linking of these unimolecular micelles into supramolecular cascades ("superaborols") will give rise to the construcation of large micellar molecules possessing shapes analogous to the parent arborol, but macroscipic in molecular dimensions. The use of these (supra)cascade polymers, as solubilizing agents, phase- transfer catalysis, resolving agents, and microencapsulation agents, will be continued.

基于数学进展在有机合成中的应用，人们正在构建一系列具有特定尺寸和形状的多方向级联聚合物(“arborol”)。这些分子有一个定义的拓扑结构，在一个完全或几乎无法接近的核心上有一个多官能化的表面。该研究将侧重于使用不同的中心核心分子、构建基块(支化分子)的组合(S)和不同的末端基团合成和表征各种级联聚合物。表面将通过改变这些端基来进行修饰，以确保可溶物和物理化学性质的侧向范围。这类聚合物的这些物理和化学性质将通过13C核磁共振波谱、电子显微镜、光散射、荧光探针法、溶解度、渗透压、电导率和质谱学的组合来表征。这些特别设计的聚合物的形状将被详细研究，以确定导致它们聚集成胶束组装的参数。这些单分子胶束共价连接成超分子级联(“超分子醇”)将导致大胶束分子的构建，这些大胶束分子的形状类似于母体阿波罗，但在分子尺寸上是大的。这些(超)级联聚合物将继续用作增溶剂、相转移催化剂、拆分剂和微胶囊剂。