Spherical Hydrophilic Polymers: Synthesis, Characterization and Applications

9901393Newkome本文所述的拟议研究是从先前NSF资助中获得的结果的系统和逻辑扩展。 本提案的首要主题涉及的树枝状聚合物的制备，结构方面，和化学性质的调查，已通过内部和外部修改（1）组合techinques检查功能基团cooperativity内branced架构和（2）的金属配体结合位点的建设纳入“高阶”树枝状网络和阵列。 根据这一目标是设计和合成的面向应用的树枝状聚合物访问形式的实用树枝状构建块，可以通过定向或静态型反应shcemes制备，并基于有据可查的合成转化。 组合技术将有助于构建具有结构多样性的新型树枝状大分子家族。 树枝状聚合物构建效率和组合技术的有用性将通过催化活性的材料分析来评估（例如，磷酸酯水解）。 内部修饰的树枝状聚合物用于制备新材料的用途也将通过树枝状组件和网络的模块化构造来举例说明。 网络制备将通过四面体单元在适当官能化时自组装的倾向和由迭代合成方法提供的结合lici的严格几何位置控制来促进。 金属络合物的形成将用于有序阵列的连接。 项目目标包括：探索内部枝晶的潜在物理化学性质和应用 用于可回收的水解催化剂的功能多样的树枝状驱动器的构建。具有能够与其他环境形成连接的区室化部分的树枝状聚合物的构建。 树枝状聚合物的功能衍生的树枝状结构单元和树枝状驱动器的制备，其能够 用于展示表面官能团的流动性。结合超支化和经典树枝状的最佳特性的树枝状驱动器的组合构建 合成技术。本研究结合了与高度支化的、专门设计的大分子的物理化学性质相关的化学研究，以及这些性质所固有的附带效用。 这项研究的结果将扩大基础的理解发生在“设计师”的反应环境中的化学现象。

9901393NewkomeThe proposed research described herein is a systematic and logical extension of the results obtained from prior NSF funding. The overriding theme of this proposal concerns the investigation of the preparation, structural aspects, and chemical propeties of dendrimers that have been internally and externally modified via (1) combinatorial techinques to examine functional group cooperativity within branced architectures and (2) the incorporation of metal ligand binding sites for the construction of "higher order" dendritic networks and arrays. Pursuant to this goal are the design and synthersis of application-oriented dendrimers accessed form utilitarian dendritic building blocks that can be prepared via directed- or statictical-type reaction shcemes and are based on well documented synthetic transformations. Combinatorial techinques will facilitate the construction of novel dendrimer families possessing constitutionally diverse fundtionality. Dendrimer construction efficiency and usefulness of the combinatorial techinique will be assessed by material analysis for catalytic activity(e.g., phosphate ester hydrolysis). Use of the internally modified dendrimers for the preparation of novel materials will also be exemplified by the modular construction of dendritic assemblies and networks. Network preparation will be facilitated by the propensity of tetrahedral units to self-assemble when appropriately functionalized and the strict geometric positional control of binding lici provided by the iterative synthetic method. Metal complex formation will be employed for the connectivity of the ordered arrays. Project goals include:Exploration of the potential physicochemical properties and applications of internal dendritic environments.Construction of functionally diverse dendrivers for use as recoverable, hydrolytic catalysts.Construction of dendrimers with compartmentalized moieties capable of forming connections with other dendrimers.Preparation of functionally derivatized dendritic building blocks and dendrivers that are capable of being used to demonstrate surface functional group mobility.Combinatorial construction of dendrivers to meld the best traits of hypebranched and classical dendritic synthetic techniques.%%%This research combines study of the chemistry associated with physicochemical properties of highly branched, specifically designed, macromolecule, with the attendant utility inherent in those properties. Results of this research will expand foundations for understanding of chemical phenomena occurring within "designer" reaction environments.