Spherical Hydrophilic Polymers: Synthesis, Characterization and Applications

本文所描述的拟议研究是对先前获得的NSF资助结果的系统和逻辑扩展。本提案的主要主题是研究树突状物的制备、结构和化学性质，这些树突状物通过(1)组合技术来检查分支结构中官能团的协同性；(2)结合金属配体结合位点来构建“高阶”树突状网络和阵列。根据这一目标，设计和合成面向应用的树状大分子，这些树状大分子可以通过定向或静态型反应方案制备，并基于有充分记录的合成转换。组合技术将有助于构建具有不同基本结构的新型树状大分子家族。树状大分子的构建效率和组合技术的实用性将通过材料分析来评估催化活性(例如。磷酸酯水解)。利用内部修饰的树状大分子制备新材料也将通过树突组装和网络的模块化结构来举例说明。四面体单元在适当功能化时自组装的倾向以及迭代合成方法提供的结合lici的严格几何位置控制将有助于网络的制备。金属配合物形成将被用于连接有序阵列。项目目标包括：探索潜在的物理化学性质和内部树突环境的应用。构建功能多样的枝晶，用于可回收的水解催化剂。树状大分子的结构，具有能够与其他树状大分子形成连接的区隔化的部分。制备功能衍生的树突结构单元和树突，能够用于证明表面官能团的迁移性。枝晶的组合构造，融合了枝晶合成技术和传统枝晶合成技术的最佳特性。这项研究结合了高度分支的，特别设计的大分子的物理化学性质的化学研究，以及这些性质所固有的效用。这项研究的结果将为理解在“设计”反应环境中发生的化学现象奠定基础。

9901393NewkomeThe proposed research described herein is a systematic and logical extension of the results obtained from prior NSF funding. The overriding theme of this proposal concerns the investigation of the preparation, structural aspects, and chemical propeties of dendrimers that have been internally and externally modified via (1) combinatorial techinques to examine functional group cooperativity within branced architectures and (2) the incorporation of metal ligand binding sites for the construction of "higher order" dendritic networks and arrays. Pursuant to this goal are the design and synthersis of application-oriented dendrimers accessed form utilitarian dendritic building blocks that can be prepared via directed- or statictical-type reaction shcemes and are based on well documented synthetic transformations. Combinatorial techinques will facilitate the construction of novel dendrimer families possessing constitutionally diverse fundtionality. Dendrimer construction efficiency and usefulness of the combinatorial techinique will be assessed by material analysis for catalytic activity(e.g., phosphate ester hydrolysis). Use of the internally modified dendrimers for the preparation of novel materials will also be exemplified by the modular construction of dendritic assemblies and networks. Network preparation will be facilitated by the propensity of tetrahedral units to self-assemble when appropriately functionalized and the strict geometric positional control of binding lici provided by the iterative synthetic method. Metal complex formation will be employed for the connectivity of the ordered arrays. Project goals include:Exploration of the potential physicochemical properties and applications of internal dendritic environments.Construction of functionally diverse dendrivers for use as recoverable, hydrolytic catalysts.Construction of dendrimers with compartmentalized moieties capable of forming connections with other dendrimers.Preparation of functionally derivatized dendritic building blocks and dendrivers that are capable of being used to demonstrate surface functional group mobility.Combinatorial construction of dendrivers to meld the best traits of hypebranched and classical dendritic synthetic techniques.%%%This research combines study of the chemistry associated with physicochemical properties of highly branched, specifically designed, macromolecule, with the attendant utility inherent in those properties. Results of this research will expand foundations for understanding of chemical phenomena occurring within "designer" reaction environments.