Spherical Hydrophilic Polymers: Synthesis, Characterization, and Applications

基于预先密集堆积的树突状大分子基础结构中的“空隙体积”，将构建一系列具有内部特定位置的金属、类金属和/或杂环部分的新型聚合物。提出的研究将侧重于具有易于功能化亲脂性内部的水溶性级联聚合物的合成和表征。这些转变将侧重于在梯级上层建筑建造后的每一代操作内部反应位点的潜力。这些单分子胶束的内部修饰将允许制备金属球，这是专门设计的水溶性催化剂。这些大分子的表征将通过核磁共振波谱、电子显微镜、光散射、荧光探针方法、溶解度、渗透压电导率和质谱等标准技术来完成。在单个分子内的胶束环境中进行化学反应的潜力将被详细研究。将继续使用这些级联聚合物作为增溶剂、微胶囊剂和宿主运输剂。本研究涉及一类新的大球形分子的合成及其性质。因为它们被设计成在结构中有空隙，所以在这些新结构中加入各种类型的功能材料是可能的。将研究它们在各种应用中的潜力。

Based on the 'void volume' incorporated into the infrastructure of pre-dense packed, dendritic macromolecules, a series of novel polymers will be constructed that possess internal, specifically located, metal, metalloid, and/or heterocyclic moieties. The proposed research will emphasize the synthesis and characterization of water-soluble cascade polymers with easily functionalized lipophilic interiors. These transformations will focus on the potential to manipulate internal reactive sites, at each generation, after cascade superstructure construction. Modification of the interior of these unimolecular micelles will allow preparation of metallospheres which are specifically designed, water-soluble catalysts. Characterization of these macromolecules will be accomplished via the standard techniques of NMR spectroscopy, electron microscopy, light-scattering, fluorescent-probe methods, solubility, osmotic pressure conductivity, and mass spectroscopy. The potential to perform chemistry within a micellar environment, inside a single molecule, will be investigated in detail. The use of these cascade polymers as solubilizing agents, microencapsulating agents, and host- transport agents will be continued. This research deals with the synthesis and properties of a new class of large spherical molecules. Because they are designed to have voids in their structure, it will be possible to incorporate various types of functional materials within these new structures. Their potential in various applications will be investigated.