Computer for Ultrastructure Research and Molecular Biology

用于超微结构研究和分子生物学的计算机

• 批准号: 8721474
• 负责人: Joachim Frank
• 金额: $ 6万
• 依托单位: New York State Department of Health and Health Research Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-15 至 1991-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8721474&HistoricalAwards=false
• 关键词: Computer; Ultrastructure; Research; Molecular; Biology

This group of investigators in structural biology utilize the conventional electron microscope and computer tomography in association with the high-voltage electron microscope. The computer-based components of these projects rely on the availability of raster graphics, large disk space, and memory. The funded equipment of this grant consists of DEC and SUN computer hardware which will provide high speed computing capability. The use of shared instrumentation is appropriate because the bulk of existing software developed in-house has been written with a view towards accommodating a wide range of applications, and because a shared facility leads to the most efficient use of resources. Visualization of the cell and its substructural components has been and continues to be one of the important goals of modern biology. Electron microscopy provides magnification powerful enough to image cellular organelles and macromolecular complexes. The complex 3-dimensional reconstruction of serial sections is performed by computer, providing a picture of these complexes. Structures to be investigated by electron microscopy and high voltage electron microscopy include ribosomes, membrane channels, components of the mitotic apparatus, and cilia.

这组结构生物学研究人员利用传统电子显微镜和计算机断层扫描与高压电子显微镜相结合。 这些项目的基于计算机的组件依赖于光栅图形、大磁盘空间和内存的可用性。 本次资助的设备由DEC和SUN计算机硬件组成，将提供高速计算能力。使用共享仪器是合适的，因为内部开发的大部分现有软件都是为了适应广泛的应用程序而编写的，并且因为共享设施可以最有效地利用资源。 细胞及其亚结构成分的可视化一直是并将继续成为现代生物学的重要目标之一。 电子显微镜提供足够强大的放大倍数来对细胞细胞器和大分子复合物进行成像。 计算机对连续截面进行复杂的 3 维重建，提供这些复合体的图像。 通过电子显微镜和高压电子显微镜研究的结构包括核糖体、膜通道、有丝分裂器的成分和纤毛。