Visualization and Modeling of Biological Complexity

生物复杂性的可视化和建模

• 批准号: 9219043
• 负责人: Joachim Frank
• 金额: $ 73.07万
• 依托单位: Health Research Incorporated/New York State Department of Health
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-15 至 1997-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9219043&HistoricalAwards=false
• 关键词: Visualization; Modeling; Biological; Complexity

9219043 Frank The understanding of biological function requires a multi- level approach to the study of structure and a mapping of the enormous complexity in an accessible way. To this end, tools must be developed, along with an appropriate computational infrastructure, that are able to visualized, match, an d combine three-dimensional data from different sources (x-ray, electron microscopy (EM) and light microscopy (LM)). Current computational tools are unable to realized opportunities clearly opened up by current computer technology. This award will support the multidisciplinary group of investigators to upgrade the computational environment in such a way that (i) it is suitable for the interpretation of 3D data from various experimental sources; (ii) it facilitates correlative 3D studies; and (ii) it becomes accessible to the biologist. Among the systems studies are the ribosome and its interaction with RNA; the mechanism of mitosis; the mechanism of excitation-contraction coupling in the muscle cell and the interactions between hippocampal pyramidal cells. The award will support the purchase of a parallel computer, a system of workstations, and the development of corresponding software. The award is being supported by the Computational Biology Activities and the Instrumentation and Instrument Development programs. ***

小行星9219043 对生物功能的理解需要多层次的方法来研究结构，并以一种可访问的方式映射巨大的复杂性。 为此，必须开发工具，沿着适当的计算基础设施，能够可视化，匹配，并联合收割机三维数据从不同的来源（X射线，电子显微镜（EM）和光学显微镜（LM））。 当前的计算工具无法实现由当前计算机技术明确打开的机会。 该奖项将支持多学科研究人员小组升级计算环境，以便（i）它适合解释来自各种实验来源的3D数据;（ii）它促进相关的3D研究;（ii）它可以被生物学家访问。 系统研究包括核糖体及其与RNA的相互作用;有丝分裂的机制;肌肉细胞中兴奋-收缩偶联的机制以及海马锥体细胞之间的相互作用。 该奖项将支持购买并行计算机，工作站系统和相应软件的开发。 该奖项得到了计算生物学活动和仪器和仪器开发计划的支持。 ***