Molecular probe development for the oxytocin and vasopressin receptors

催产素和加压素受体的分子探针开发

• 批准号: DE150100784
• 负责人: A/Prof Markus Muttenthaler
• 金额: $ 25.75万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-05-04 至 2018-05-03
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE150100784
• 关键词: Molecular; probe; development; oxytocin; vasopressin

The oxytocin and vasopressin receptors are part of a 600 million year old signalling system that is widely distributed in the kingdom of life. It is involved in many fundamental physiological functions, however we still lack a complete toolbox of selective probes to delineate the individual receptor subtypes. This project aims to introduce a novel and innovative strategy that uses state-of-the art discovery techniques to identify selective ligands in nature. Leads will be developed into molecular probes to facilitate in-depth studies of this system. This strategy is applicable to other systems and the outcomes will contribute to a significant advancement of knowledge in chemical biology.

催产素和加压素受体是6亿年前广泛分布于生命王国的信号系统的一部分。它参与了许多基本的生理功能，但我们仍然缺乏一个完整的工具箱的选择性探针来描绘个别受体亚型。该项目旨在引入一种新颖的创新策略，使用最先进的发现技术来识别自然界中的选择性配体。引线将被开发成分子探针，以促进对该系统的深入研究。这一战略适用于其他系统，其成果将有助于化学生物学知识的重大进步。