Molecular probe development for high specificity and spatiotemporal control

高特异性和时空控制的分子探针开发

• 批准号: FT210100266
• 负责人: A/Prof Markus Muttenthaler
• 金额: $ 64.09万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-02-28 至 2026-02-27
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT210100266
• 关键词: Molecular; probe; development; specificity; spatiotemporal

This project aims at developing next-generation molecular probes with enhanced specificity and spatiotemporal control for the study of proteins and neuropeptide signalling. It addresses recognised knowledge gaps and technical bottlenecks in neuropeptide and memory research. Expected outcomes include a deeper molecular understanding of long-term memory formation and the role of neuropeptides in this process, as well as innovative chemistry strategies and novel molecular probes to advance fundamental research across the chemical and biological sciences. Anticipated benefits include technological innovations of relevance to Australia’s biotechnology sector and enhanced capacity for cross-disciplinary collaboration.

该项目旨在开发具有增强特异性和时空控制的下一代分子探针，用于研究蛋白质和神经肽信号。它解决了神经肽和记忆研究中公认的知识差距和技术瓶颈。预期成果包括对长期记忆形成和神经肽在这一过程中的作用的更深入的分子理解，以及创新的化学策略和新型分子探针，以推进化学和生物科学的基础研究。预期的好处包括与澳大利亚生物技术部门有关的技术创新和加强跨学科合作的能力。