US-Argentina Cooperative Research on Studies on the Mechanism of Action of Aldosterone in Brain

美阿根廷合作研究醛固酮脑作用机制

• 批准号: 8802246
• 负责人: Bruce McEwen
• 金额: $ 1.77万
• 依托单位: Rockefeller University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-15 至 1990-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8802246&HistoricalAwards=false
• 关键词: US; Argentina; Cooperative; Research; Studies

This award supports cooperative research in neuroendocrinology between Dr. Bruce McEwen of the Rockefeller University and Dr. Alexandro De Nicola at the Institute of Biology and Experimental Medicine in Buenos Aires, Argentina. This work will identify the characteristics of and the degree of overlap between two receptor systems for steroid hormones in the brain. Understanding the communication between steroidal receptors is important to interpreting interactions between other neurotransmitters and receptors. The use of new molecular biological methodology will lead to new advances in brain neuroscience. The principal investigators have a history of previous successful collaboration and a former student of Dr. De Nicola, Dr. Coirini, is now a post-doc in Dr. McEwen's laboratory. Both laboratories are well equipped for their part of the research and therefore significant contributions can be made by both sides in investigating the regulation of mineralocorticoid receptors by glucocorticoids and the regulation of glucocorticoid receptors by mineralocorticoids. Also, the levels of these hormones and how the binding activity is affected by the regulation will be determined. This work will continue a productive four-year collaboration.

该奖项支持洛克菲勒大学的 Bruce McEwen 博士和阿根廷布宜诺斯艾利斯生物与实验医学研究所的 Alexandro De Nicola 博士在神经内分泌学方面的合作研究。这项工作将确定大脑中两个类固醇激素受体系统的特征和重叠程度。了解类固醇受体之间的通讯对于解释其他神经递质和受体之间的相互作用很重要。新分子生物学方法的使用将带来脑神经科学的新进展。 主要研究人员之前有过成功合作的历史，De Nicola 博士的前学生 Coirini 博士现在是 McEwen 博士实验室的博士后。两个实验室都为各自的研究配备了良好的设备，因此双方可以在研究糖皮质激素对盐皮质激素受体的调节以及盐皮质激素对糖皮质激素受体的调节方面做出重大贡献。此外，还将确定这些激素的水平以及结合活性如何受到调节的影响。这项工作将继续富有成效的四年合作。