U.S.-Argentina Cooperative Research: Studies on the Mechanism of Action of Aldosterone in Brain

该奖项由美国-阿根廷合作科学项目颁发，支持洛克菲勒大学神经内分泌实验室的Bruce S. McEwen教授和布宜诺斯艾利斯大学医学院的Alejandro F. De Nicola博士在神经内分泌学方面的合作研究。阿根廷。本项目的重点是研究醛固酮在大脑中的作用机制。本研究将探讨mRNA在脑内的分布以及糖皮质激素和矿皮质激素对Na， K atp酶α亚基三种亚型的调控作用。原位杂交组织化学将用于定位和绘制大脑各区域的mRNA，并研究其在雌雄大鼠大脑中可能存在性别差异和雌激素影响的糖皮质激素和矿皮质激素的区域调节。该奖项将促进美国与阿根廷卓有成效的合作关系的延续。

This award from the U.S.-Argentina Cooperative Science Program supports collaborative research in neuroendocrinology to be conducted by Professor Bruce S. McEwen of the Laboratory of Neuroendocrinology at the Rockefeller University and Dr. Alejandro F. De Nicola of the Faculty of Medicine at the University of Buenos Aires, Argentina. The focus of the project is to study the mechanism of action of aldosterone in the brain. The research will investigate the distribution within the brain and regulation by glucocorticoids and mineralocorticoids of mRNA's for the three subtypes of the alpha subunit of Na, K ATPase. In situ hybridization histochemistry will be used to localize and map mRNA's in various brain regions and to study their regional regulation by glutocorticoids and mineralocorticoids in male and female rat brains where there may also be sex differences and estrogen affects. The award will foster continuation of a fruitful U.S.-Argentina collaboration.