U.S.-Argentina Cooperative Research: Studies on the Mechanism of Action of Aldosterone in Brain

这项来自美国-阿根廷合作科学计划的奖项支持洛克菲勒大学神经内分泌学实验室的布鲁斯·S·麦克尤恩教授和医学院的亚历杭德罗·F·德·尼古拉博士在神经内分泌学方面的合作研究。布宜诺斯艾利斯大学阿根廷。该项目的重点是研究醛固酮在大脑中的作用机制。本研究将探讨Na，K-ATPaseα亚基的三种亚型在脑内的分布以及糖皮质激素和盐皮质激素对其表达的调节。用原位杂交组织化学方法定位和定位不同脑区的mRNA，研究糖皮质激素和盐皮质激素对雄性和雌性大鼠脑内不同脑区基因表达的调节。该奖项将促进美国和阿根廷卓有成效的合作的继续。

This award from the U.S.-Argentina Cooperative Science Program supports collaborative research in neuroendocrinology to be conducted by Professor Bruce S. McEwen of the Laboratory of Neuroendocrinology at the Rockefeller University and Dr. Alejandro F. De Nicola of the Faculty of Medicine at the University of Buenos Aires, Argentina. The focus of the project is to study the mechanism of action of aldosterone in the brain. The research will investigate the distribution within the brain and regulation by glucocorticoids and mineralocorticoids of mRNA's for the three subtypes of the alpha subunit of Na, K ATPase. In situ hybridization histochemistry will be used to localize and map mRNA's in various brain regions and to study their regional regulation by glutocorticoids and mineralocorticoids in male and female rat brains where there may also be sex differences and estrogen affects. The award will foster continuation of a fruitful U.S.-Argentina collaboration.