U.S.-Argentina Cooperative Research: Studies on the Mechanism of Action of Aldosterone in Brain

美国的这个奖-阿根廷合作科学 该计划支持合作研究， 神经内分泌学将由布鲁斯教授进行 S.神经内分泌学实验室的麦克尤恩说， 洛克菲勒大学和Alejandro F. De 尼可拉是牛津大学医学院的教授， 阿根廷布宜诺斯艾利斯 该项目的重点是 研究醛固酮在肝硬化中的作用机制， 个脑袋 本研究将调查 大脑和糖皮质激素的调节， 盐皮质激素的mRNA的三种亚型， Na，K ATP酶α亚基。 原位 杂交组织化学将用于定位 绘制不同大脑区域的mRNA， 糖皮质激素对它们的区域调节， 雄性和雌性大鼠大脑中的盐皮质激素， 也可能存在性别差异和雌激素 影响。 该奖项将促进一个 富有成效的美国-阿根廷合作。

This award from the U.S.-Argentina Cooperative Science Program supports collaborative research in neuroendocrinology to be conducted by Professor Bruce S. McEwen of the Laboratory of Neuroendocrinology at the Rockefeller University and Dr. Alejandro F. De Nicola of the Faculty of Medicine at the University of Buenos Aires, Argentina. The focus of the project is to study the mechanism of action of aldosterone in the brain. The research will investigate the distribution within the brain and regulation by glucocorticoids and mineralocorticoids of mRNA's for the three subtypes of the alpha subunit of Na, K ATPase. In situ hybridization histochemistry will be used to localize and map mRNA's in various brain regions and to study their regional regulation by glutocorticoids and mineralocorticoids in male and female rat brains where there may also be sex differences and estrogen affects. The award will foster continuation of a fruitful U.S.-Argentina collaboration.