U.S.-Argentina Cooperative Studies on the Mechanism of Action of Aldosterone in the Brain

美阿根廷合作研究醛固酮在大脑中的作用机制

• 批准号: 9503716
• 负责人: Bruce McEwen
• 金额: $ 2万
• 依托单位: Rockefeller University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9503716&HistoricalAwards=false
• 关键词: U.S.; Argentina; Cooperative; Studies; Mechanism

9503716 McEwen This U.S.-Argentina Cooperative Research grant will support the collaborative research of Dr. Alejandro de Nicola of Argentina (Instituto de Biologia y Medicina Experimental) and Dr. Bruce McEwen of the U.S. (Rockefeller University) to investigate the role of Na,K-ATPase in the amygdala in the control of salt appetite in the rat caused by injections of deoxycorticosterone (DOC). The effects of the mineralocorticoid agonist, aldosterone, as well as the glucocorticoid receptor agonist, Ru 28362, on the amygdala and hippocampus will also be studied. The laboratories of both Drs. de Nicola and McEwen are well established and recognized for the high quality of research which has come out of them. The questions proposed generate much interest in the scientific community; in particular, the neural basis of steroid control of salt appetite in rats is recognized as an important problem. Both in Argentina and in New York, young scientists will be given an opportunity, as part of this grant, to participate in an important area of research in well-equipped laboratories. ***

麦克尤恩9503716 这个美国-阿根廷合作研究赠款将支持阿根廷的Alejandro de Nicola博士（生物学和医学实验研究所）和美国的布鲁斯·麦克尤恩博士（洛克菲勒大学）的合作研究，以调查杏仁核中的Na，K-ATPase在控制注射脱氧皮质酮（DOC）引起的大鼠盐食欲中的作用。还将研究盐皮质激素激动剂醛固酮以及糖皮质激素受体激动剂Ru 28362对杏仁核和海马的影响。 德·尼古拉博士和麦克尤恩博士的实验室都是建立良好的，并因其高质量的研究而受到认可。 提出的问题在科学界产生了很大的兴趣，特别是，类固醇控制大鼠盐食欲的神经基础被认为是一个重要的问题。 在阿根廷和纽约，作为这项赠款的一部分，青年科学家将有机会在设备齐全的实验室参加一个重要的研究领域。 ***