U.S.-Argentina Cooperative Research: Studies on the Mechanism of Action of Aldosterone in Brain

美阿根廷合作研究：醛固酮脑作用机制研究

• 批准号: 9802428
• 负责人: Bruce McEwen
• 金额: $ 2万
• 依托单位: Rockefeller University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-11-01 至 2000-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9802428&HistoricalAwards=false
• 关键词: U.S.; Argentina; Cooperative; Research; Studies

9802428 McEwen This Americas Program award will fund a two-year cooperative research project between Dr. Bruce McEwen, Rockefeller University, and Dr. Alejandro F. de Nicola, Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina, on regulation and control of salt appetite. Salt appetite is associated with an important homeostatic, motivated behavior, and serves as a model for studying appetites and appetitive behaviors. These studies will provide insights into the neural basis of motivational states and behavior. Using state of the art techniques linking molecular biology and classical physiological approaches, the colaborators will focus on the amygdala as an important target area for mineralocorticoid induction of salt appetite. In situ hybridization histochemistry will be utilized to further investigate the role of adrenal steroid receptors. The project will address important, unanswered questions on the fundamental function of the brain in the regulation of fluid metabolism. This collaboration will combine the expertise of the US side in neurosciences and molecular biology, with the expertise of the Argentinean side in in physiology, pharmacology and neuroendocrinology. ***

麦克尤恩9802428 这个美洲计划奖将资助洛克菲勒大学的布鲁斯麦克尤恩博士和亚历杭德罗F。de Nicola，Instituto de Biologia y Medicina Experimental，Buenos Aires，Argentina，关于盐食欲的调节和控制。 盐食欲与一种重要的自我平衡、动机行为有关，是研究食欲和食欲行为的模型。 这些研究将提供深入了解动机状态和行为的神经基础。 利用分子生物学和经典生理学方法相结合的最新技术，colaborators将专注于杏仁核作为盐皮质激素诱导盐食欲的重要靶区。 原位杂交组织化学将用于进一步研究肾上腺类固醇受体的作用。 该项目将解决重要的，悬而未决的问题，在液体代谢的调节大脑的基本功能。 这项合作将联合收割机结合美国在神经科学和分子生物学方面的专业知识，以及阿根廷在生理学，药理学和神经内分泌学方面的专业知识。 ***