Development of LC/MS Techniques for Analysis of Nonvolatile Environmental Pollutants and Metabolites

这项妇女研究计划研究机会补助金是在分析和表面化学的一般领域以及色谱和质谱的子领域。在从1988年7月1日开始的12个月期间，Dietrich教授将利用她在色谱法和质谱法方面的丰富专业知识，开发液相色谱-质谱法（LC/MS）混合技术的新技能，并将其应用于各种环境问题的研究，特别是与有害废物管理有关的问题。计划中的技能发展活动既包括独立工作，也包括国家环境健康科学研究所的合作研究。这些活动将有助于Dietrich教授在弗吉尼亚理工学院和州立大学的实验室建立一个有竞争力的独立研究项目。本项目将探索的研究领域，即LC/MS技术在多组分环境样品分析中的开发和应用，对基础科学和公共卫生都具有广泛的重要性。这项工作的结果可能对环境化学和质谱分析领域以及健康科学产生重大影响；它可能导致确定处置和处理危险废物所必需的新技术。

This Research Opportunities for Women Research Planning Grant is in the general area of Analytical and Surface Chemistry and in the subfields of chromatography and mass spectrometry. During the twelve month period beginning 1 July 1988, Professor Dietrich will draw upon her considerable expertise in both chromatography and mass spectrometry to develop new skills in hybrid liquid chromatography-mass spectrometry (LC/MS) techniques which she will apply to the study of various environmental problems, particularly those relating to hazardous waste management. The planned skill development activities include both independent work and also collaborative research at the National Institute for Environmental Health Science. These activities should contribute to Professor Dietrich's establishing a competitive independent research program in her laboratory at Virginia Polytechnic Institute and State University during the tenure of this Research Planning Grant award. The research area that will be explored in this project, namely the development and application of LC/MS techniques for the analysis of multicomponent environmental samples, is broadly important to both basic science and public health. The results of this work could impact significantly on the fields of environmental chemistry and mass spectrometry, as well as upon the health sciences; it could lead to the identification of new technology that is necessary for the disposal and treatment of hazardous waste.