Method Development/Validation Multi-laboratory validation of method for Arsenic speciation in seafood using LC-ICP-MS (Discipline D: Special Projects Analytical Track 3)

项目总结 这个特别项目的总体目标是对以下项目的可行性进行初步的探索性调查 建立一种新的测定海产品中砷(As)形态的方法 LC-电感耦合等离子体质谱分离检测拟议的项目将利用目前的专业知识和 沃兹沃斯中心的能力，那里已经开发了一种简单的LC-ICP-MS方法，以及 它可以被多个实验室验证为在整个蕨类网络中使用。具体目标将 包括探讨将As(III)和As(V)结合起来的可行性，将前者氧化为后者，以产生 单一无机砷物种(IAS)。其他目标将包括决定多少不同的AS物种应该 在所提出的方法中被捕获，而认识到校准标准只存在于有限数量的AS 物种。一个关键的目标将是以海鲜为基础生产合适的候选参考材料 产品矩阵可以同质化，并分发到多个实验室，以实现第一个实验室间 学习。其他目标将包括对提议的方法进行单一实验室验证，以及设计 首次进行实验室间循环调度，收集有关网络功能的基准数据

PROJECT SUMMARY The overall goal of this special project is to conduct a preliminary, exploratory investigation of the feasibility of developing a new method for arsenic (As) speciation in seafood based on a simple extraction procedure with separation and detection using LC-ICP-MS. The proposed project will leverage the current expertise and capabilities at the Wadsworth Center, where a simple LC-ICP-MS method has already been developed, and which could be validated for use across the FERN network by multiple laboratories. Specific objectives will include exploring the feasibility of combining As(III) and As(V) by oxidizing the former to the latter, to produce a single inorganic As species (iAs). Other objectives will include deciding how many different As species should be captured in the proposed method, while recognizing calibration standards exist only for limited number of As species. A key objective will be to produce a suitable candidate reference material based on a seafood product matrix that can be homogenized, and distributed to multiple laboratories for the first interlaboratory study. Other objectives will include a single laboratory validation of the proposed method, and the design of the first interlaboratory round robin to gather baseline data on network capabilities