The Structure and Function of Triocornaviruses

Triocornaviruses的结构和功能

• 批准号: 8817057
• 负责人: John Johnson
• 金额: $ 46.82万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-15 至 1994-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8817057&HistoricalAwards=false
• 关键词: Structure; Function; Triocornaviruses

Dr. Johnson is studying particle structure, stability, and assembly in a family of viruses called the tricornaviruses. The method of analysis will be primarily X-ray crystallography, although a variety of biochemical methods will be employed to produce samples that are suitable for crystallization. Collaborations with experts in molecular genetics and spectroscopy will be undertaken to fully exploit the crystallographic technique and experiments. The overall goal will be to use these structures to attempt to design biophysical, biochemical and molecular genetic experiments that address function. Investigations have shown that viruses infecting plants, insects and mammals share common structural and functional themes although there are remarkable and unexpected differences between viruses infecting the same host. Understanding viral structures and their relationships to function will enable one to relate viruses to each other and to their hosts in terms of structural and physical properties at the molecular level.***

约翰逊博士正在研究粒子结构、稳定性和 在一个叫做三角核糖核酸病毒的病毒家族中组装。 分析方法将主要是X射线 晶体学，虽然各种生物化学方法 将用于生产适合于 晶化 与分子生物学领域的专家合作 将进行遗传学和光谱学研究， 晶体学技术和实验。 整体 我们的目标是利用这些结构来设计 生物物理、生物化学和分子遗传学实验 地址功能。 调查表明，感染植物的病毒， 昆虫和哺乳动物有着共同的结构和功能 主题虽然有显着的和意想不到的 感染同一宿主的病毒之间的差异。 了解病毒结构及其与 函数将使人们能够将病毒相互关联， 在结构和物理性质方面， 分子水平。*