The Structure and Function of Triocornaviruses

Triocornaviruses的结构和功能

• 批准号: 8817057
• 负责人: John Johnson
• 金额: $ 46.82万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-15 至 1994-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8817057&HistoricalAwards=false
• 关键词: Structure; Function; Triocornaviruses

Dr. Johnson is studying particle structure, stability, and assembly in a family of viruses called the tricornaviruses. The method of analysis will be primarily X-ray crystallography, although a variety of biochemical methods will be employed to produce samples that are suitable for crystallization. Collaborations with experts in molecular genetics and spectroscopy will be undertaken to fully exploit the crystallographic technique and experiments. The overall goal will be to use these structures to attempt to design biophysical, biochemical and molecular genetic experiments that address function. Investigations have shown that viruses infecting plants, insects and mammals share common structural and functional themes although there are remarkable and unexpected differences between viruses infecting the same host. Understanding viral structures and their relationships to function will enable one to relate viruses to each other and to their hosts in terms of structural and physical properties at the molecular level.***

约翰逊博士正在研究一个称为三角病毒的病毒家族中的粒子结构，稳定性和组装。 分析方法将主要是X射线晶体学，尽管将采用多种生化方法来生产适合结晶的样品。 将与分子遗传学和光谱方面的专家合作，以充分利用晶体学技术和实验。 总体目标是使用这些结构尝试设计解决功能的生物物理，生化和分子遗传实验。 研究表明，感染植物，昆虫和哺乳动物的病毒具有共同的结构和功能主题，尽管感染同一宿主的病毒之间存在显着且意外的差异。 了解病毒结构及其功能的关系将使人们可以在分子层的结构和物理特性方面将病毒彼此相关。***