U.S.-Japan Cooperative Research: Plant Cell Bioprocess Engineering for Production of Secondary Metabolites

该奖项将支持一个为期两年的合作研究项目， 杜威教授Y. Ryu和他的同事在密歇根大学 加州，戴维斯和教授Shintaro Furusaki， 东京，以及其他日本大学的同事。 项目 涉及植物生物技术的多学科基础研究。 主要重点将是建立一个知识库， 广泛应用于生物工艺技术， 来自遗传改良植物细胞重要次生代谢产物 线 次级代谢产物是细胞代谢产物， 细胞的生长和存活所必需的，与原发性 代谢物，它们是。 已经发现了一些次级代谢产物 作为药物、着色剂和调味剂非常有用， 用于化妆品和其他经济上重要的产品的成分。 日本人在这方面的研究和开发方面走在前列。 区 美国和日本的合作教师在这方面 目前的项目在植物生物技术，植物 生物化学、植物遗传学、植物细胞生物学和生物化学 工程. 研究计划将集中在（1）生化设计 和植物细胞的遗传构建， 次级代谢产物的医学和经济重要性， 生物反应器大量细胞培养条件;（2）设计和开发 一种适用于大规模植物细胞的新型生物反应器系统， （3）基础生物过程工程研究， 植物细胞生物反应器系统和生物过程优化 最有效地生产次级代谢产物。 这个项目是 预计将建立一个合作研究计划，并关闭 美国和日本科学家在该领域的工作关系 植物生物技术。 它的目标是做出重大贡献 为了促进我们对一般原则的理解， 植物生物技术可以转化为生物技术 工程实践的有益应用，特别是对 生产具有经济和医学重要性的次级代谢产物。

This award will support a two-year cooperative research project between Professor Dewey D. Y. Ryu and colleagues at the University of California, Davis, and Professor Shintaro Furusaki, University of Tokyo, and co-workers at other Japanese universities. The project involves multi-disciplinary basic research in plant biotechnology. Major focus will be on the development of a knowledge base having broad application to bioprocess technology for the production of important secondary metabolites from genetically improved plant cell lines. Secondary metabolites are cellular metabolic products not essential to the cell's growth and survival, in contrast to primary metabolites, which are. Some secondary metabolites have been found to be very useful as medicinals, coloring and flavoring agents, components for cosmetics, and other economically important products. The Japanese are at the forefront in research and development in this area. The collaborating U.S. and Japanese faculty members in this current project have collective expertise in plant biotechnology, plant biochemistry, plant genetics, plant cell biology, and biochemical engineering. The research program will focus on (1) biochemical design and genetic construction of plant cells for efficient production of secondary metabolites of medical and economic importance under bioreactor mass cell cultivation conditions; (2) design and development of a novel bioreactor system suitable for large-scale plant cell cultivation; and (3) fundamental bioprocess engineering studies on the plant cell bioreactor system and bioprocess optimization for the most efficient production of secondary metabolites. This project is expected to establish a collaborative research program and a close working relationship between U.S. and Japanese scientists in the area of plant biotechnology. It aims for a significant contribution toward advancement of our understanding of generic principles of plant biotechnology which can be translated to biotechnology engineering practices for useful application, especially for the production of secondary metabolites of economic and medical importance.