Transition Metal Disulfur Monoxide (S2O) Complexes, Their Synthesis and Reaction Chemistry

有机合成计划支持马克·威尔克教授的工作。威克森林大学的威尔克参与了一种独特的含有一氧化二硫的复合物的制备和化学行为的研究。这些配合物是由附着在金属上的含碳化合物组成的。虽然它们本身很有趣，但这些新的配合物可以用来开发合成策略，以制备大量重要的含硫材料。许多重要的生物活性化合物含有硫作为其结构的一部分，一直是实验室制备的有趣挑战。标准和一般方法无法解决合成问题，而Welker的程序正在解决这一需求。这个项目的目标是：1)用过渡金属配合物捕获和稳定一氧化二硫；2)利用这些配合物高效地合成有机硫化合物。将要开发的方法是一般的，应该得到广泛的应用。这一点很重要，因为许多具有药理意义的含硫化合物可能会通过新的方案得到解决。就其本身而言，对一氧化二硫的基本配位化学的制备、表征和研究将提供一系列的基础知识。

The Organic Synthesis Program supports the work of Prof. Mark Welker. Welker, of Wake Forest University, is involved in the preparation and chemical behavior of unique complexes that contain trapped disulfur monoxide. These complexes are made up of carbon-containing compounds attached to metals. Although interesting in their own right, these novel complexes can be used to develop synthetic strategies for preparing a host of important sulfur-containing materials. Many important bioactive compounds contain sulfur as part of their structure and have been interesting challenges to laboratory preparation. Standard and general methods are not available to address the synthesis problems, and Welker's program is addressing this need. The goals of this project are to 1) trap and stabilize disulfur monoxide with transition metal complexes; and 2) make use of these complexes in efficient syntheses of organosulfur compounds. The approaches to be developed are general and should find wide application. This is important since a number of pharmacologically significant sulfur-containing compounds might be addressed by the new protocols. In its own right, the preparation, characterization and study of basic coordination chemistry of disulfur monoxide will provide a range of fundamental knowledge.