Transition Metal Disulfur Monoxide (S2O) Complexes, Their Synthesis and Reaction Chemistry

过渡金属一氧化二硫 (S2O) 配合物、其合成和反应化学

• 批准号: 8817985
• 负责人: Mark Welker
• 金额: --
• 依托单位: Wake Forest University
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1992-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8817985&HistoricalAwards=false
• 关键词: Transition; Metal; Disulfur; Monoxide; S2O

The Organic Synthesis Program supports the work of Prof. Mark Welker. Welker, of Wake Forest University, is involved in the preparation and chemical behavior of unique complexes that contain trapped disulfur monoxide. These complexes are made up of carbon-containing compounds attached to metals. Although interesting in their own right, these novel complexes can be used to develop synthetic strategies for preparing a host of important sulfur-containing materials. Many important bioactive compounds contain sulfur as part of their structure and have been interesting challenges to laboratory preparation. Standard and general methods are not available to address the synthesis problems, and Welker's program is addressing this need. The goals of this project are to 1) trap and stabilize disulfur monoxide with transition metal complexes; and 2) make use of these complexes in efficient syntheses of organosulfur compounds. The approaches to be developed are general and should find wide application. This is important since a number of pharmacologically significant sulfur-containing compounds might be addressed by the new protocols. In its own right, the preparation, characterization and study of basic coordination chemistry of disulfur monoxide will provide a range of fundamental knowledge.

有机合成计划支持马克教授的工作 韦尔克 来自维克森林大学的韦尔克参与了 制备和化学行为的独特的复合物， 含有捕获的一氧化二硫。 这些复合物是由 由附着在金属上的含碳化合物组成。 虽然 有趣的是，这些新颖的复合物可以是 用于开发合成策略， 重要的含硫材料。 许多重要 生物活性化合物含有硫作为其结构的一部分 对实验室准备工作提出了有趣的挑战。 没有标准和通用方法来解决 合成问题，韦尔克的计划正在解决这个问题， 需要的 该项目的目标是1）捕获和稳定 一氧化二硫与过渡金属络合物;和2）制备 这些络合物在有机硫的有效合成中的用途 化合物. 有待制定的办法是一般性的， 应该得到广泛应用。 这一点很重要，因为 重要的含硫化合物 可能会被新的协议所解决。 就其本身而言， 碱性配位化合物的制备、表征和研究 一氧化二硫的化学性质将提供一系列 基础知识。