Catalytic Metal Mediated Enantioselective Cycloaddition Reactions

催化金属介导的对映选择性环加成反应

• 批准号: 0104083
• 负责人: Mark Welker
• 金额: --
• 依托单位: Wake Forest University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-15 至 2005-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0104083&HistoricalAwards=false
• 关键词: Catalytic; Metal; Mediated; Enantioselective; Cycloaddition

Professor Mark E. Welker in the Department of Chemistry at Wake Forest University is supported by the Organic and Macromolecular Chemistry Program for his studies on the development of exo-selective and/or enantioselective Diels-Alder reactions that are catalyzed by transition metals. Series of chiral ligands, transition metals, and reducing agents that do not react or react very slowing with the dienophile carbonyl and double bonds will be screened for their efficacy in the catalytic cycle. This methodology will be used to synthesize several cis-decalin ring systems related to biologically significant compounds.With the support of the Organic and Macromolecular Program, Professor Welker is investigating new ways to form six-membered rings with precise control over the three-dimensional spatial arrangement of the substituents. These reactions will be catalyzed by small amounts of transition metals. By using catalytic amounts, savings in terms of material and waste disposal costs will be realized. The new methodology also will be utilized to prepare the bicyclic core structures of several biologically active organic compounds.

Mark E.韦尔克在化学系在维克森林大学是由有机和大分子化学计划的支持，他的研究外选择性和/或对映选择性狄尔斯-阿尔德反应的发展是由过渡金属催化。 将筛选不与亲二烯体羰基和双键反应或反应非常缓慢的一系列手性配体、过渡金属和还原剂在催化循环中的功效。 该方法将用于合成几种与生物重要化合物相关的顺式十氢萘环系统。在有机和大分子计划的支持下，Welker教授正在研究形成六元环的新方法，并精确控制取代基的三维空间排列。 这些反应将被少量的过渡金属催化。 通过使用催化量，将实现材料和废物处理成本方面的节省。 新方法也将用于制备几种具有生物活性的有机化合物的双环核心结构。