MRI: Acquisition of an inductively coupled plasma mass spectrometer for interdisciplinary applications in science and technology

该奖项来自主要研究仪器计划（MRI），并得到生命过程化学（CLP）和化学研究仪器（CRIF）计划的额外支持，资助维克森林大学收购电感耦合等离子体质谱仪（ICP-MS）。该仪器是一种强大的分析工具，可用于测定各种来源的样品中的痕量元素。该仪器使跨学科合作研究能够阐明微量元素在不同化学，生物和环境过程中的作用和作用。 由于其高灵敏度和多元素能力，微波辅助消解（MAD）的ICP-MS在从环境科学和政策到半导体和材料科学，食品生产和生物医学行业的领域中至关重要。该仪器的使用与温斯洛普大学和温斯顿-塞勒姆州立大学共享，用于教学和研究。 这项建议的目的是加强研究，特别是在以下领域：（a）研究放牧生态系统中饲料营养物质的可获得性;（B）使用铂络合物作为治疗剂和细胞探针;（c）监测北卡罗来纳州夏洛特地区卡托巴流域的金属和植物补救;（d）研究在放牧生态系统中的饲料营养物质的可获得性;（e）研究在放牧生态系统中的饲料营养物质的可获得性;（f）研究在放牧生态系统中的饲料营养物质的可获得性;（g（d）应用电感耦合等离子体质谱仪（ICP-MS）早期诊断骨质疏松症;（e）研究革兰氏阳性菌中金属酶的生物成因和功能;及（f）进行标准稀释分析，以测定药物配方中的微量元素。

This award, from the Major Research Instrumentation Program (MRI) with additional support from the Chemistry of Life Processes (CLP) and Chemistry Research Instrumentation (CRIF) Programs, funds the acquisition of an inductively coupled plasma mass spectrometer (ICP-MS) by Wake Forest University. The instrument is a powerful analytical tool to determine trace elements in samples from various sources. The instrumentation enables collaborative interdisciplinary research to elucidate the effects and roles of trace elements in diverse chemical, biological and environmental processes. Because of its high sensitivity and multi-element capabilities, ICP-MS with microwave assisted digestion (MAD) is essential in fields from environmental science and policy to semiconductor and material sciences, food production, and biomedical industries. Use of the instrument is shared with Winthrop University and Winston-Salem State University for teaching and research. It is employed in several outreach projects involving middle and high school students.The proposal is aimed at enhancing research especially in areas such as: (a) studying the availability of forage nutrients in grazing ecosystems; (b) using platinum complexes as therapeutics and cellular probes; (c) monitoring metals and phytoremediation across the Catawba watershed in the Charlotte, NC, region; (d) applying ICP-MS to the early diagnosis of osteoporosis; (e) studying the biogenesis and function of metalloenzymes in Gram-positive bacteria; and (f) carrying out standard dilution analysis for trace element determination in medicine formulations.