MRI: Acquisition of an inductively coupled plasma mass spectrometer for interdisciplinary applications in science and technology

MRI：购买电感耦合等离子体质谱仪，用于科学技术的跨学科应用

• 批准号: 1531698
• 负责人: Mark Welker
• 金额: $ 23.99万
• 依托单位: Wake Forest University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1531698&HistoricalAwards=false
• 关键词: MRI; Acquisition; inductively; coupled; plasma

This award, from the Major Research Instrumentation Program (MRI) with additional support from the Chemistry of Life Processes (CLP) and Chemistry Research Instrumentation (CRIF) Programs, funds the acquisition of an inductively coupled plasma mass spectrometer (ICP-MS) by Wake Forest University. The instrument is a powerful analytical tool to determine trace elements in samples from various sources. The instrumentation enables collaborative interdisciplinary research to elucidate the effects and roles of trace elements in diverse chemical, biological and environmental processes. Because of its high sensitivity and multi-element capabilities, ICP-MS with microwave assisted digestion (MAD) is essential in fields from environmental science and policy to semiconductor and material sciences, food production, and biomedical industries. Use of the instrument is shared with Winthrop University and Winston-Salem State University for teaching and research. It is employed in several outreach projects involving middle and high school students.The proposal is aimed at enhancing research especially in areas such as: (a) studying the availability of forage nutrients in grazing ecosystems; (b) using platinum complexes as therapeutics and cellular probes; (c) monitoring metals and phytoremediation across the Catawba watershed in the Charlotte, NC, region; (d) applying ICP-MS to the early diagnosis of osteoporosis; (e) studying the biogenesis and function of metalloenzymes in Gram-positive bacteria; and (f) carrying out standard dilution analysis for trace element determination in medicine formulations.

该奖项来自主要研究仪器计划（MRI），并得到了生命过程化学（CLP）和化学研究仪器（CRIF）计划的额外支持，资助维克森林大学购买电感耦合等离子体质谱计（ICP-MS）。该仪器是一种功能强大的分析工具，可测定各种来源样品中的微量元素。该仪器使跨学科合作研究能够阐明微量元素在各种化学，生物和环境过程中的作用和作用。由于其高灵敏度和多元素能力，微波辅助消解ICP-MS （MAD）在环境科学和政策、半导体和材料科学、食品生产和生物医学行业等领域都是必不可少的。该仪器与温斯罗普大学和温斯顿-塞勒姆州立大学共享，用于教学和研究。它被用于几个涉及中学生和高中生的外展项目。该提案旨在加强研究，特别是在以下领域：(a)研究放牧生态系统中饲料营养物质的可用性；(b)使用铂配合物作为治疗剂和细胞探针；(c)监测北卡罗来纳州夏洛特地区Catawba流域的金属和植物修复；(d) ICP-MS在骨质疏松早期诊断中的应用；(e)研究革兰氏阳性菌中金属酶的生物发生和功能；(f)对药物制剂中微量元素进行标准稀释分析。