Sequential Reactions of Main Group Element Substituted Dienes
主族元素取代二烯的顺序反应
基本信息
- 批准号:0749759
- 负责人:
- 金额:$ 37.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-02-15 至 2013-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project will continue work on the development of catalytic, exo selective and enantioselective Diels-Alder reactions. Boron and silicon-substituted dienes, which offer practical advantages over transition metal-substituted dienes in terms of cost and disposal, will be prepared and utilized in catalytic chemistry and tandem reactions. These dienes can be used to reverse the normal endo selectivity of Diels-Alder reactions and provide access to new cycloadduct stereoisomers in high yield, diastereoselectivity and enantioselectivity. This synthetic method will provide access to relative and absolute cycloadduct stereochemistries that were not readily available previously through endo-selective Diels-Alder reactions of the polymerization-prone Z-dienes. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Mark Welker of the Department of Chemistry at Wake Forest University. Professor Welker's research efforts revolve around the development of tandem Diels-Alder/hydrolysis and Diels-Alder/cross coupling reactions. The products of these tandem reactions have biological activities ranging from insect anti-feedants to biomedical science applications. The successful development of the methodology therefore will have an impact on synthesis in the pharmaceutical and agricultural industries.
该项目将继续致力于开发催化、外选择性和对映选择性Diels-Alder反应。 硼和硅取代的二烯,这提供了实际的优势,在成本和处置方面的过渡金属取代的二烯,将被制备和利用在催化化学和串联反应。 这些二烯可用于逆转Diels-Alder反应的正常内选择性,并以高产率、非对映体选择性和对映体选择性提供新的环加成物立体异构体。 这种合成方法将提供获得相对和绝对环加成物立体化学的途径,所述相对和绝对环加成物立体化学先前不容易通过聚合倾向Z-二烯的内选择性Diels-Alder反应获得。 凭借该奖项,有机和大分子化学项目正在支持维克森林大学化学系Mark Welker教授的研究。 Welker教授的研究工作围绕串联Diels-Alder/水解和Diels-Alder/交叉偶联反应的发展。 这些串联反应的产物具有从昆虫拒食剂到生物医学科学应用的生物活性。 因此,该方法的成功开发将对制药和农业工业的合成产生影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mark Welker其他文献
Mark Welker的其他文献
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{{ truncateString('Mark Welker', 18)}}的其他基金
MRI: Acquisition of an inductively coupled plasma mass spectrometer for interdisciplinary applications in science and technology
MRI:购买电感耦合等离子体质谱仪,用于科学技术的跨学科应用
- 批准号:
1531698 - 财政年份:2015
- 资助金额:
$ 37.8万 - 项目类别:
Standard Grant
Preparation and Tandem Reactions of Main Group Substituted Dienes
主族取代二烯的制备及串联反应
- 批准号:
0450722 - 财政年份:2005
- 资助金额:
$ 37.8万 - 项目类别:
Standard Grant
Catalytic Metal Mediated Enantioselective Cycloaddition Reactions
催化金属介导的对映选择性环加成反应
- 批准号:
0104083 - 财政年份:2001
- 资助金额:
$ 37.8万 - 项目类别:
Standard Grant
Transition-Metal Mediated Cycloaddition Reactions
过渡金属介导的环加成反应
- 批准号:
9321454 - 财政年份:1994
- 资助金额:
$ 37.8万 - 项目类别:
Continuing grant
NATO EAST EUROPE: Senior Guest Scientist Suppoort for Professor Stefan Toma
北约东欧:Stefan Toma 教授的高级客座科学家支持
- 批准号:
9450187 - 财政年份:1994
- 资助金额:
$ 37.8万 - 项目类别:
Standard Grant
Transition Metal Disulfur Monoxide (S2O) Complexes, Their Synthesis and Reaction Chemistry
过渡金属一氧化二硫 (S2O) 配合物、其合成和反应化学
- 批准号:
8817985 - 财政年份:1989
- 资助金额:
$ 37.8万 - 项目类别:
Continuing grant
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