Preparation and Tandem Reactions of Main Group Substituted Dienes

主族取代二烯的制备及串联反应

• 批准号: 0450722
• 负责人: Mark Welker
• 金额: $ 36万
• 依托单位: Wake Forest University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-15 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0450722&HistoricalAwards=false
• 关键词: Preparation; Tandem; Reactions; Main; Group

The focus of this research will be on metal-mediated Diels Alder chemistry. As one goal, the preparation of 2-main group element-substituted 1,3-dienes followed by tandem Diels-Alder/cross-coupling reactions will be carried out. Another goal will be to develop methodology to facilitate the tandem transmetallation/Diels-Alder reactions and sequential transmetallation/Diels-Alder/cross- coupling reactions of main group substituted-dienes. Also, using the Diels Alder approach, the core structures in the cis-clerodane terpenes, compounds having interesting biological properties, will be synthesized. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Mark E. Welker in the Department of Chemistry at Wake Forest University. Professor Welker will focus his work on the development of Diels Alder methodology using main group substituted-dienes. When this methodology is employed in combination with transmetallation and cross-coupling reactions, products that are core structures for natural product synthesis result. The work has potential for broader impact in the pharmaceutical and agricultural industries and the project serves as an excellent venue for the training of undergraduates and graduate students.

本研究的重点是金属介导的Diels桤木化学。 作为一个目标，将进行2-主族元素取代的1，3-二烯的制备，然后进行串联Diels-Alder/交叉偶联反应。 另一个目标将是开发促进主基团取代的二烯的串联transmetabolites/Diels-Alder反应和顺序transmetabolites/Diels-Alder/交叉偶联反应的方法。此外，使用Diels桤木方法，将合成具有有趣的生物学性质的化合物顺式克罗烷萜烯中的核心结构。有了这个奖项，有机和高分子化学计划是支持博士马克E。韦尔克在维克森林大学化学系。 教授韦尔克将集中他的工作在发展的狄尔斯桤木方法使用主组取代二烯。 当这种方法与transmetabolism和交叉偶联反应结合使用时，产生作为天然产物合成的核心结构的产物。这项工作有可能在制药和农业行业产生更广泛的影响，该项目是本科生和研究生培训的绝佳场所。