Center for the Neurobiology of Learning and Memory

学习和记忆神经生物学中心

• 批准号: 8821219
• 负责人: William Greenough
• 金额: $ 60.13万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-03-15 至 1996-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8821219&HistoricalAwards=false
• 关键词: Center; Neurobiology; Learning; Memory

In order to optimize interdisciplinary approaches that capitalize upon new technical and theoretical developments, a Center for the Neurobiology of Learning and Memory is being established at the Beckman Institute (currently under construction) of the University of Illinois at Urbana-Champaign . This center will serve as 1) a Resource Center, providing advanced facilities for the study of the learning and memory process, including optical imaging (for histological studies), multi-electrode array recording (to allow functional patterns of interactions among neurons to be examined), and rapid tissue freezing (for assessment of sub-cellular dynamics); 2) a Research Center that fosters communication and collaboration among scientists pursuing common and related problems of memory and neural plasticity; 3) a Training Center which prepares graduate and postdoctoral investigators for research careers in learning and memory, and 4) a Recruiting Center that to attract outstanding young people to scientific careers. This program of scientific development and interaction is taking advantage of the unusual resources of the Beckman Institute and the University of Illinois Urbana-Champaign campus in neurobiology, interdisciplinary collaboration and cooperation, and strengths of the component disciplines of neural and behavioral sciences. Technical foci of the Center include large array neurophysiological recording facilities, with which the interactions among brain regions during learning are studied; rapid freezing facilities for examining brain slices in vitro, (with which the nature of plasticity at the level of the synapse is studied), and neuroanatomical imaging and analysis facilities (where memory processes are studied at levels ranging from the molecular to the morphological). Several types of learning are being studied, including discriminative conditioning, acquisition of motor skill, acquisition of acoustic discriminative ability, and the traditional psychological animal learning tasks such as mazes. In addition, current "models" of memory (such as long-term potentiation and kindling) are being examined. The function of the Center for the Neurobiology of Learning and Memory is to advance our knowledge of brain substrates of learning and memory from the cellular and molecular to the integrative brain system levels.

为了优化跨学科的方法， 根据新的技术和理论发展， 学习和记忆的神经生物学正在建立在 贝克曼研究所（目前正在建设中） 伊利诺伊大学香槟分校。 这个中心将 作为1）资源中心，提供先进的设施， 学习和记忆过程的研究，包括光学 成像（用于组织学研究），多电极阵列 记录（以允许相互作用的功能模式， 神经元检查）和快速组织冷冻（用于 亚细胞动力学评估）; 2）研究中心， 促进科学家之间的沟通和合作， 记忆和神经可塑性的常见和相关问题; 3）a 培养研究生和博士后的培训中心 学习和记忆研究职业的调查员，以及4） 一个招聘中心，吸引优秀的年轻人， 科学事业。 这个科学发展和互动的项目 贝克曼研究所的不寻常资源的优势， 伊利诺伊大学香槟分校 神经生物学，跨学科协作与合作， 和神经和神经科学的组成学科的优势， 行为科学 该中心的技术重点包括大型 阵列神经生理记录设施， 研究了学习过程中脑区之间的相互作用; 用于体外脑切片检查的快速冷冻设备， (with突触层面的可塑性 以及神经解剖成像和分析设施 （记忆过程的研究水平从 分子到形态学）。 目前正在研究几种类型的学习，包括 辨别性条件反射，运动技能的获得， 声学辨别能力的获得， 传统的心理动物学习任务，如迷宫。 此外，目前的记忆“模型”（如长期记忆） 增强和点燃）正在进行研究。 的功能 学习和记忆神经生物学中心 推进我们对学习和记忆的大脑基质的了解 从细胞和分子到整合的大脑系统 程度.