Center for the Neurobiology of Learning and Memory

为了优化利用新的技术和理论发展的跨学科方法，伊利诺伊大学香槟分校贝克曼研究所(目前正在建设中)正在建立一个学习和记忆神经生物学中心。该中心将作为1)资源中心，为学习和记忆过程的研究提供先进的设施，包括光学成像(用于组织学研究)、多电极阵列记录(以允许检查神经元之间相互作用的功能模式)和快速组织冷冻(用于亚细胞动力学评估)；2)研究中心，促进研究共同和相关的记忆和神经可塑性问题的科学家之间的交流和合作；3)培训中心，为研究生和博士后研究人员在学习和记忆方面的研究生涯做准备；以及4)招聘中心，吸引优秀的年轻人投身科学事业。这一科学发展和互动计划正在利用贝克曼研究所和伊利诺伊大学厄巴纳-香槟分校在神经生物学、跨学科协作和合作以及神经和行为科学组成学科的优势方面的独特资源。该中心的技术重点包括大型神经生理记录设备，用于研究学习过程中大脑区域之间的相互作用；用于体外检查脑片的快速冷冻设备，用于研究突触水平的可塑性；以及神经解剖成像和分析设备(从分子到形态的水平研究记忆过程)。人们正在研究几种类型的学习，包括辨别条件反射、运动技能的获得、声学辨别能力的获得，以及传统的心理动物学习任务，如迷宫。此外，目前的记忆“模型”(如长时程增强和点燃)也在研究之中。学习和记忆神经生物学中心的功能是将我们对学习和记忆的大脑底物的知识从细胞和分子水平提升到整合的大脑系统水平。

In order to optimize interdisciplinary approaches that capitalize upon new technical and theoretical developments, a Center for the Neurobiology of Learning and Memory is being established at the Beckman Institute (currently under construction) of the University of Illinois at Urbana-Champaign . This center will serve as 1) a Resource Center, providing advanced facilities for the study of the learning and memory process, including optical imaging (for histological studies), multi-electrode array recording (to allow functional patterns of interactions among neurons to be examined), and rapid tissue freezing (for assessment of sub-cellular dynamics); 2) a Research Center that fosters communication and collaboration among scientists pursuing common and related problems of memory and neural plasticity; 3) a Training Center which prepares graduate and postdoctoral investigators for research careers in learning and memory, and 4) a Recruiting Center that to attract outstanding young people to scientific careers. This program of scientific development and interaction is taking advantage of the unusual resources of the Beckman Institute and the University of Illinois Urbana-Champaign campus in neurobiology, interdisciplinary collaboration and cooperation, and strengths of the component disciplines of neural and behavioral sciences. Technical foci of the Center include large array neurophysiological recording facilities, with which the interactions among brain regions during learning are studied; rapid freezing facilities for examining brain slices in vitro, (with which the nature of plasticity at the level of the synapse is studied), and neuroanatomical imaging and analysis facilities (where memory processes are studied at levels ranging from the molecular to the morphological). Several types of learning are being studied, including discriminative conditioning, acquisition of motor skill, acquisition of acoustic discriminative ability, and the traditional psychological animal learning tasks such as mazes. In addition, current "models" of memory (such as long-term potentiation and kindling) are being examined. The function of the Center for the Neurobiology of Learning and Memory is to advance our knowledge of brain substrates of learning and memory from the cellular and molecular to the integrative brain system levels.