Comparing reward learning among adolescents and adults with MDD and using reward-related neurobiology to predict future reward-related learning

比较患有 MDD 的青少年和成人的奖励学习，并使用奖励相关的神经生物学来预测未来的奖励相关学习

• 批准号: 10678493
• 负责人: Amanda C Del Giacco
• 金额: $ 4.77万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-22 至 2025-02-21
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678493
• 关键词: Academy; Adolescence; Adolescent; Adolescent Psychiatry; Adult; American; Behavior; Brain; Cause of Death; Child Psychiatry; Control Groups; Data Set; Decision Making; Depressed mood; Disease; Disease remission; Early identification; Emergency Situation; Functional disorder; Future; Goals; Height; Impairment; Individual; Individual Differences; Intervention; Learning; Life; Link; Literature; Major Depressive Disorder; Measures; Mediating; Mediation; Mental Depression; Mental Health; Mental disorders; Neurobiology; Neuronal Plasticity; Onset of illness; Outcome; Pharmaceutical Preparations; Phenotype; Play; Prevention; Psychopathology; Psychotherapy; Research; Rest; Rewards; Risk; Role; Severities; Stimulus; Substance Use Disorder; Suicide; Suicide attempt; System; Time; Treatment Efficacy; Ventral Striatum; Visit; Youth; adolescent-onset depression; age group; behavioral phenotyping; child depression; comorbidity; depressive symptoms; emerging adult; endophenotype; evidence base; falls; hedonic; high risk; improved; individualized medicine; insight; learned behavior; neural; neural circuit; neurobiological mechanism; neuroimaging; peer; personalized intervention; response; reward circuitry; reward processing; standard care; substance use; success; suicidal risk; treatment response; treatment strategy; young adult

PROJECT SUMMARY The number of mental health concerns and emergency visits for suspected suicide attempts in youth during 2021 has led to a declared national emergency by the American Academy of Child and Adolescent Psychiatry. The consequences of major depressive disorder (MDD) onset during adolescence are substantial. Adolescents with MDD are at higher risk for suicidality, the second leading cause of death in this age group, and for developing additional mental health disorders in adulthood. Despite considerable efforts, efficacy of gold- standard treatment for MDD remains low. For these reasons, research has aimed to identify early neurobiological markers related to depression onset and severity. Progress in the field of neuroimaging has identified aberrant reward circuitry (i.e., dampened activation in the reward system in anticipation or receipt of reward) as a potential endophenotype for depression. However, reward processing is not limited to hedonics, and depression may be better characterized by how diminished hedonics impact other aspects of the reward system, such as reward learning. Previous literature supports the notion that MDD is associated with dampened reward-learning behavior in adults; however, less is known about how adolescent reward-learning behavior may be impacted by MDD. Of note, studying reward dysfunction and reward learning during adolescence is critical due to heightened reward sensitivity and ongoing neuroplasticity occurring during this time. The goal of this proposal is to examine how reward learning is impacted by MDD in adolescence, as well as how neurobiological mechanisms of reward responsivity and reward circuitry predict future reward-learning behavior in adulthood. The first aim is to be the first study to compare reward-learning behavior among adolescents and adults with and without MDD. Then, capitalizing on an existing dataset, the second aim is to assess the associations between adolescent neurobiological reward responsivity, resting-state functional connectivity (rsFC) of the reward system, and task- based functional connectivity and future reward learning. Filling the gap in our understanding of how reward learning is impacted by MDD in adolescents and how neurobiological mechanisms of reward circuitry relate to future reward-driven behavior may further our understanding of risk for depression and help to inform early prevention efforts. Improved understanding of these mechanisms also may help to inform individualized treatment strategies for youth based on individual neurobiology and behavior.

项目总结 青少年的精神健康问题和疑似自杀企图的急诊次数 在2021年期间导致美国儿童和青少年学院宣布全国进入紧急状态 精神病学。严重抑郁障碍(MDD)在青春期发病的后果是严重的。 患有MDD的青少年自杀的风险更高，自杀是这个年龄段的第二大死亡原因，以及 在成年后发展成额外的精神健康障碍。尽管付出了相当大的努力，但黄金的功效- MDD的标准治疗仍然很低。出于这些原因，研究的目标是确定早期的神经生物学 与抑郁症发病和严重程度相关的标记物。神经成像领域的进展已经确定了异常 潜在的奖赏回路(即，在预期或收到奖赏时抑制奖赏系统的激活) 抑郁症的内表型。然而，奖励处理并不局限于享乐者，抑郁症可能是 更好的特点是享乐主义的减少如何影响奖励系统的其他方面，如奖励 学习。以前的文献支持MDD与受抑的奖赏学习行为相关的概念 然而，关于青少年的奖赏学习行为可能会受到MDD的影响，人们知之甚少。的 注意，研究青春期的奖赏障碍和奖赏学习是至关重要的，因为奖赏增加了。 敏感度和持续的神经可塑性发生在这段时间。这项提案的目标是研究如何 青春期的奖赏学习受到MDD的影响，以及奖赏的神经生物学机制 响应性和奖赏回路预测了成年后未来的奖赏学习行为。第一个目标是成为 第一项研究比较患有和不患有MDD的青少年和成年人的奖励学习行为。然后, 利用现有的数据集，第二个目标是评估青少年之间的联系 神经生物学奖赏响应性、奖赏系统的静息状态功能连接(RsFC)和任务- 基于功能连接和未来奖励学习。填补我们在理解如何奖励方面的空白 青少年学习受到MDD的影响，以及奖赏回路的神经生物学机制如何与 未来的奖励驱动行为可能会加深我们对抑郁风险的理解，并有助于及早了解 预防工作。对这些机制的更好理解也可能有助于向个性化 基于个体神经生物学和行为的青少年治疗策略。