Convergent Functional Groups

聚合功能组

• 批准号: 8910788
• 负责人: Julius Rebek
• 金额: --
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1992-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8910788&HistoricalAwards=false
• 关键词: Convergent; Functional; Groups

This project by Julius Rebek within the Organic Dynamics Program, is aimed at the design, synthesis and study of host molecules that can bind to a variety of bioorganic ligands. These latter target molecules include heterocyclic bases, peptides and nucleic acid components. The selectivity of these systems will provide important information about molecular recognition, and its role in biological processes. Receptors for adenine have been refined to include molecular chelation; these systems feature simultaneous Watson-Crick, and Hoogsteen base-pairing and aryl stacking interactions. The thermodynamics of the complexation events will be examined, and are expected to reveal the intrinsic binding provided by the polarizable aromatic surfaces in contact with the nucleic acid bases in a number of solvents. Base-pairing in model receptors will be used to drive acyl transfer reactions to learn about the characteristics of self-replicating systems. This aspect of the project will invlove kinetic studies, especially those involving competitive inhibitors.

Julius Rebek在有机动力学中的这个项目 程序，是针对主机的设计、综合和研究 可以与多种生物有机配体结合的分子。 这些后一种靶分子包括杂环碱基， 肽和核酸组分。 这些选择性 系统将提供有关分子的重要信息， 识别及其在生物过程中的作用。 腺嘌呤的受体已被提炼为包括分子 螯合;这些系统具有同时沃森-克里克， Hoogsteen碱基配对和芳基堆积相互作用。 的 将检查络合事件的热力学，并且 有望揭示由蛋白质提供的内在结合， 与核酸接触的可极化芳香族表面 在一些溶剂中的碱。 模型受体中的碱基配对 将用于驱动酰基转移反应， 自我复制系统的特征。 该方面 该项目的一部分将涉及动力学研究，尤其是那些 涉及竞争性抑制剂。