Template Effects and Self-replicating Systems

模板效应和自我复制系统

• 批准号: 9119995
• 负责人: Julius Rebek
• 金额: --
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-01 至 1995-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9119995&HistoricalAwards=false
• 关键词: Template; Effects; Self; replicating; Systems

This grant from the Organic Dynamics Program supports the continuing work of Professor Julius Rebek, Jr. at Massachusetts Institute of Technology. Systems designed to precisely fix the positions of molecules in space in order to control their reactivity with neighboring molecules will be studied. In particular, a previously reported self-replicating system will be examined in greater detail. An imide-ester that can bind adenine, but not undergo internal acylation, will be used to shut down the intramolecular base pair components and promote exponential growth. More lipophilic and soluble Kemp triacid imides will also be used so that the concentrations can be increased. Proximity complexation in order to enhance the rate of amide formation between two nucleic acid components will also be examined. %%% Self-replicating reactions in which the product acts as a template for its own formation will be studied. Such systems stand at the interface of chemistry and biology, and provide models for selection, competition and mutation; the essential components of chemical evolution. The synthesis of efficient replicators and the design of nucleic acid-like templates for the synthesis of peptide sequences will be undertaken. These new molecules are expected to offer a link between today's biological structures and their prebiotic counterparts.

有机动力学计划的这笔赠款支持 Julius Rebek，Jr.教授的持续工作在马萨诸塞州 理工学院 系统旨在精确地修复 分子在空间中的位置，以控制它们的 将研究与邻近分子的反应性。 在 特别是，以前报道的自我复制系统将 进行更详细的检查。 一种酰亚胺酯， 腺嘌呤，但不进行内部酰化，将用于 关闭分子内碱基对成分， 指数增长 更亲脂和可溶的肯普三酸 也将使用酰亚胺，使得浓度可以 增加 邻位络合，以提高速率 两种核酸组分之间的酰胺形成将 也要检查。 %%% 自我复制反应，其中产品作为一个 将研究其自身形成的模板。 这样的系统 站在化学和生物学的交界处， 选择、竞争和突变的模型; 化学进化的组成部分。 高效合成 复制子和设计核酸样模板， 将进行肽序列的合成。 这些 新的分子有望提供一个联系， 生物结构和它们的前生物对应物。