U.S.-Japan Cooperative Research: Chiral Protonation/ Deprotonation

美日合作研究：手性质子化/去质子化

• 批准号: 9117009
• 负责人: Julius Rebek
• 金额: $ 1.12万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9117009&HistoricalAwards=false
• 关键词: U.S.; Japan; Cooperative; Research; Chiral

This award will support a two-year U.S.-Japan cooperative science project between Professor Julius Rebek, Department of Chemistry, Massachusetts Institute of Technology, and Professor Kenji Koga, Faculty of Pharmaceutical Sciences, University of Tokyo. The project involves the investigation of catalytic proton transfer agents for asymmetric chemical synthesis. This cooperative effort seeks to develop the techniques and understanding of factors governing the stereoelectronics of protonation and deprotonation. This will require a focus on both the proton source as well as the trajectory of proton transfer. Professor Rebek has performed extensive studies of stereoelectronic effects at carboxyl function and the chemistry of molecular recognition. Professor Koga has a program in asymmetric deprotonation reactions and the chemistry of lithiated amine bases. Their collaboration in this project draws on the complementarity of their research programs.

该奖项将支持一个为期两年的美日合作科学项目，该项目由麻省理工学院化学系朱利叶斯·雷贝克教授和东京大学药学院古贺健二教授共同开展。该项目涉及不对称化学合成的催化质子转移剂的研究。这项合作努力旨在发展技术和理解控制质子化和去质子化立体电子学的因素。这需要同时关注质子源和质子转移的轨迹。Rebek教授对羧基功能的立体电子效应和分子识别化学进行了广泛的研究。古贺教授的研究方向是不对称去质子化反应和胺基锂化化学。他们在这个项目上的合作得益于他们研究项目的互补性。