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Development of Tandem Mass Spectrometry for Analysis of Complex Biomolecules

用于复杂生物分子分析的串联质谱法的发展

基本信息

批准号：
8913656
负责人：
Catherine Fenselau
金额：
$ 47.66万
依托单位：
University of Maryland Baltimore County
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1989
资助国家：
美国
起止时间：
1989-12-01 至 1992-11-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=8913656&HistoricalAwards=false
关键词：
Development Tandem Mass Spectrometry Analysis

项目摘要

This award continues support of Tandem Mass Spectrometry activities at the Mid Atlantic Mass Spectrometry (MAMS) laboratory at the University of Maryland Baltimore County (UMBC). One of several approaches to mass spectrometry (MS), tandem MS provides high resolution measurements of compounds with the high molecular weights typical of proteins, nucleic acids and other biopolymers. Efforts sponsored by this award will focus on improving techniques for analysis of proteins and peptides using the tandem instrument; a variety of collaborative research projects will be initiated or continued. Mass spectrometry plays an increasingly important role in the structural analysis of biomolecules. Information about protein sequence and structure, including naturally occurring modifications of proteins, and similar kinds of information about polysaccharides and other branched chain polymers are obtained with great difficulty by other techniques. The MAMS laboratory includes facilities at UMBC and at The Johns Hopkins University School of Medicine. Both were established as shared instrument resources for collaborative and service projects. Because of the considerable expense of acquisition and operation of tandem MS instruments, this type of analysis is not routinely available at most research institutions. The UMBC facility provides the research community at UMBC and at numerous other institutions with access to the kind of skilled mass spectrometry needed in many areas of modern biological research.

该奖项继续支持串联质谱中大西洋质谱实验室（MAMS）在马里兰州巴尔的摩县大学（UMBC）。之一质谱（MS）的几种方法，串联MS提供了高分子化合物的高分辨率测量蛋白质、核酸和其他生物聚合物的典型重量。由该奖项赞助的努力将集中在改进技术上用于使用串联仪器分析蛋白质和肽; 将启动或开展各种合作研究项目持续期间内的质谱分析在生物医学中起着越来越重要的作用。生物分子结构分析。蛋白质信息序列和结构，包括天然存在的蛋白质的修饰，以及类似的信息，得到多糖和其它支链聚合物通过其他技术非常困难。 MAMS实验室包括UMBC和约翰霍普金斯大学的设施医学院的。两者都是作为共同工具而建立的合作和服务项目的资源。因为购置和操作串联质谱仪的费用相当高仪器，这种类型的分析是不定期提供的，大多数研究机构。 UMBC设施提供研究社区在UMBC和许多其他机构，获得许多国家所需的熟练质谱分析技术，现代生物学研究领域。