Instrument Development: High Performance Electrostatic Linear Ion Trap Mass Spectrometry and Tandem Mass Spectrometry

质谱仪在许多分子测量至关重要的领域发挥着重要作用，如生命科学、环境科学、能源、安全等。质谱仪的重要特征包括它可以确定分子质量和可获得的质量范围的分辨率和精度，以及实用的仪器特性，如尺寸、重量、功耗和成本。在化学系化学测量和成像计划的支持下，普渡大学的Scott McLuckey博士和他的团队试图开发一种概念上的新的简单的质量分析方法，将令人印象深刻的性能与潜在的小尺寸、低重量、低功耗和相对较低的成本结合在一起。这项工作承诺使高性能质谱学更广泛地为各个领域的科学家所用，同时为研究生和本科生提供宝贵的培训机会。麦勒基正在开发一种基于相对离子镜的相对较小的静电线性离子陷阱。该仪器将用于高性能质谱学和串联质谱学应用，无论是作为更大系统的组件还是作为独立设备。这项工作的目标是在分析时间远低于一秒的情况下，质量分辨率达到数万，并具有使用几种解离方法进行串联质谱分析实验的能力。最终的结果将是一个高度灵活和强大的工具，它足够简单，可以在学术实验室中构建，以支持专门的实验。对于商业开发来说，支持一系列常用的实验也可能是有吸引力的。可能的应用领域从现场测量(包括地外应用)到基于实验室的测量，这些测量需要以相对较低的成本获得高质量分辨率和质量精度。制造双离子反射镜装置相对容易，这也将有助于在专门的研究工具中采用这项技术，这些工具是为了解决用商业仪器无法解决的研究问题而建造的。

Mass spectrometry plays a major role in many areas where molecular measurements are critical, such as the life sciences, the environmental sciences, energy, security, etc. Important characteristics of a mass spectrometer include the resolution and accuracy with which it can determine molecular masses and the range of masses accessible, as well as practical instrumental features such as size, weight, power consumption, and cost. With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Dr. Scott McLuckey and his group at Purdue University seek to develop a conceptually new and simple means for mass analysis that combines impressive performance capabilities with potentially small size, low weight, low power consumption and relatively low cost. The work promises to make high performance mass spectrometry much more widely accessible to scientists across a wide range of fields, while providing valuable training opportunities for graduate and undergraduate students.Dr. McLuckey is developing a relatively small electrostatic linear ion trap based on opposing ion mirrors. The instrument will be useful for high-performance mass spectrometry and tandem mass spectrometry applications either as a component of larger systems or as a stand-alone device. The work targets mass resolution in the tens of thousands in analysis times well under one second, with capabilities for tandem mass spectrometry experiments using several dissociation methods. The net result will be a highly flexible and powerful tool that is simple enough to be built in academic laboratories for support of specialized experiments. It may also be attractive for commercial development to support a wide range of commonly performed experiments. Possible application areas range from field measurements (including extraterrestrial applications) to laboratory-based measurements that require high mass resolution and mass accuracy at relatively low cost. The relative ease with which dual-ion mirror devices can be fabricated will also facilitate the adoption of this technology in specialized research tools that are constructed to address research problems that cannot be addressed with commercially available instruments.