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Development of Tandem Mass Spectrometry for Analysis of Complex Biomolecules.

用于分析复杂生物分子的串联质谱法的发展。

基本信息

批准号：
9013981
负责人：
Catherine Fenselau
金额：
$ 132.97万
依托单位：
University of Maryland Baltimore County
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1991
资助国家：
美国
起止时间：
1991-02-15 至 1995-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9013981&HistoricalAwards=false
关键词：
Development Tandem Mass Spectrometry Analysis

项目摘要

This award continues support of Tandem Mass Spectrometry activities at the Mid Atlantic Mass Spectrometry (MAMS) laboratory at the University of Maryland Baltimore County (UMBC). One of several approaches to mass spectrometry (MS), tandem MS provides high resolution measurements of compounds with the high molecular weights typical of proteins, nucleic acids and other biopolymers. Efforts sponsored by this award will focus on improving techniques for analysis of proteins, glycoproteins and carbohydrates using the tandem instrument; a variety of collaborative research projects will be initiated or continued, and training activities at the pre- and post doctoral level will continue. Mass spectrometry plays an increasingly important role in the structural analysis of biomolecules. Information about protein sequence and structure, including naturally occurring modifications of proteins, and similar kinds of information about polysaccharides and other branched chain polymers are obtained with great difficulty by other techniques. The MAMS laboratory includes facilities at UMBC and at The Johns Hopkins University School of Medicine. Both were established as shared instrument resources for collaborative and service projects. Because of the considerable expense of acquisition and operation of tandem MS instruments, this type of analysis is not routinely available at most research institutions. The UMBC facility provides the research community at UMBC and at numerous other institutions with access to the kind of skilled mass spectrometry needed in many areas of modern biological research.

该奖项继续支持马里兰大学巴尔的摩县分校(UMBC)大西洋中部质谱学(MAMS)实验室的串联质谱学活动。作为几种质谱学方法之一，串联质谱仪提供了蛋白质、核酸和其他生物聚合物所特有的高相对分子质量化合物的高分辨率测量。该奖项赞助的工作将侧重于改进使用串联仪器分析蛋白质、糖蛋白和碳水化合物的技术；将启动或继续开展各种合作研究项目，并将继续开展博士后和博士后培训活动。质谱学在生物分子结构分析中发挥着越来越重要的作用。有关蛋白质序列和结构的信息，包括蛋白质的自然修饰，以及关于多糖和其他支链聚合物的类似信息，都很难通过其他技术获得。MAMS实验室包括密歇根大学和约翰霍普金斯大学医学院的设施。两者都是作为协作和服务项目的共享仪器资源而建立的。由于购买和操作串联质谱仪的费用相当高，这种类型的分析在大多数研究机构中不是常规可用的。UMBC设施为UMBC和许多其他机构的研究界提供了现代生物学研究许多领域所需的那种熟练的质谱学。