Advanced CCD-Based Synchrotron Area Detector for Structural Biology

该开发项目为研究人员提供了同步加速器x射线束流线的电子区域探测器系统，该系统设计用于收集和处理蛋白质晶体和其他生物结构的衍射数据。探测器使数据收集的效率、数据的质量和问题的复杂性有了实质性的提高，可以用同步加速器源来研究。这些研究揭示的结构信息将对我们在酶学、免疫学、病毒学、蛋白质组装和生物工程等领域的理解至关重要。该设计采用了最新的技术进步，提供了一个紧凑的探测器系统，直径为115毫米，分辨率为0.1毫米，动态范围为4000:1，数据采集速率为5mb /s。它采用光纤锥直接耦合x射线图像转换器，图像增强器和1024 x 1024像素（或更大）CCD芯片。将在同步加速器束流线上为该仪器的用户提供培训。将向希望制造或获得探测器系统或其任何组成部分副本的研究人员和其他人员提供协助和文件。

This development project provides research investigators at synchrotron X-ray beam lines withan electronic area detector system designed for collecting and processing diffraction data from protein crystals and other biological structures. The detector makes possible a substantial increase in the efficiencyof data collection, the quality of the data, and the complexity of the problems can be investigated with synchrotron sources. The structural information revealed by these studies will be vitally important to our understanding in the fields of enzymology, immunology, virology, protein assemby and bioengineering. The design employs recent technological advances to provide a compact detector system with a 115 mm diameter area, 0.1 mm resolution, a 4000:1 dynamic range, and a sustained 5 mbytes/s data acquisition rate. It incorporates fiber optic tapers to directly couple the X-ray image converter, image intensifier, and 1024 x 1024-pixel (or larger) CCD chip. Training will be provided for users of this instrument at synchrotron beam lines. Assistance and documentation will be provided to researchers and others who wish to build or obtain copies of the detector system or any of its components.