Advanced CCD-Based Synchrotron Area Detector for Structural Biology

这一开发项目为研究人员提供了具有电子面积探测器系统的同步加速器X射线束线，该系统旨在收集和处理来自蛋白质晶体和其他生物结构的衍射数据。该探测器大大提高了数据收集的效率、数据的质量和问题的复杂性，可以用同步加速器来研究。这些研究揭示的结构信息对于我们在酶学、免疫学、病毒学、蛋白质组装和生物工程领域的理解将是至关重要的。该设计采用了最新的技术进步，提供了一种紧凑的探测器系统，其直径为115 mm，分辨率为0.1 mm，动态范围为4000：1，数据采集率为5兆字节/S。它结合了光纤锥体，以直接耦合X射线图像转换器、图像增强器和1024 x 1024像素(或更大)的CCD芯片。将在同步加速器束线上为该仪器的使用者提供培训。将向希望建造或获得探测器系统或其任何部件副本的研究人员和其他人提供援助和文件。

This development project provides research investigators at synchrotron X-ray beam lines withan electronic area detector system designed for collecting and processing diffraction data from protein crystals and other biological structures. The detector makes possible a substantial increase in the efficiencyof data collection, the quality of the data, and the complexity of the problems can be investigated with synchrotron sources. The structural information revealed by these studies will be vitally important to our understanding in the fields of enzymology, immunology, virology, protein assemby and bioengineering. The design employs recent technological advances to provide a compact detector system with a 115 mm diameter area, 0.1 mm resolution, a 4000:1 dynamic range, and a sustained 5 mbytes/s data acquisition rate. It incorporates fiber optic tapers to directly couple the X-ray image converter, image intensifier, and 1024 x 1024-pixel (or larger) CCD chip. Training will be provided for users of this instrument at synchrotron beam lines. Assistance and documentation will be provided to researchers and others who wish to build or obtain copies of the detector system or any of its components.