Development of a high sensitivity optical microscopy based on Nüvü's electron-multiplying CCD camera for real-time imaging of sub-threshold membrane potential dynamics

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This Engage project aims to form an industry-university partnership between INRS and Nüvü Caméra on high**sensitivity optical neuroimaging. The overall objective of this six-month project is to demonstrate optical**voltage imaging using an electron-multiplying (EM) CCD camera from Nüvü under a microscopic setting. Four**milestones are proposed, which involves assembling the hardware, writing the software, and conducting**proof-of-concept experiments. Prof. Liang's group and Nüvü have necessary and complementary expertise that**encompasses all research tasks proposed in this application. Both sides are committed to frequent interaction**and communication to ensure the progress of this project and to facilitate the technology transfer.**Aiming to demonstrate the feasibility of Nüvü's EMCCD camera on a major-brand microscope platform, this**project is expected to significantly benefit Nüvü by boosting up its sales to solidify its current technical team**with the potential to open new positions, and by enhancing its reputation in the biomedical field through the**visibility and publicity of the disseminated results. In addition, this project has compelling scientific merits,**because Nüvü's EMCCD camera can potentially provide a considerably better sensitivity in measurement. All**these activities will support the future knowledge-based economy of Canada.