Purchase of Nuclear Magnetic Resonance Spectrometers

核磁共振波谱仪采购

• 批准号: 8915028
• 负责人: Stephen Lippard
• 金额: --
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-02-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8915028&HistoricalAwards=false
• 关键词: Purchase; Nuclear; Magnetic; Resonance; Spectrometers

A detailed study of intra and intermolecular interactions in a more complicated structures -- DNA, polypetides and small proteins, complex natural products, polymetallic species and enzyme mimics requires less routine 1D NMR experiments, pulse sequences for various 2D NMR experiments, solvent suppression, and variable temperature experiments. Multinuclear high field NMRs are ideally suited for use in these more complicated structures. The results from these NMR studies are useful in areas such as polymers and catalysis. This award from the Chemistry Shared Instrumentation Program will help the Department of Chemistry at M.I.T. acquire two high field mulitnuclear NMRs. The 300 and 500 MHz NMR spectrometers will be used for multinuclear research investigations in the following areas of chemistry: 1. Enzyme mechanisms 2. Protein conformation 3. Bioinorganic chemistry 4. Synthesis of polypeptides and proteins 5. Synthetic methods and molecular design of catalsts The spectrometers will be used primarily for 2D NMR and multinuclear NMR spectroscopy.

详细研究了分子内和分子间的相互作用， 更复杂的结构-- DNA，多肽和小的 蛋白质、复杂天然产物、多金属物种和 酶模拟物需要较少的常规1D NMR实验，脉冲 用于各种2D NMR实验的序列，溶剂抑制， 和变温实验。 多核强场 NMR非常适合在这些更复杂的环境中使用。 结构. 从这些NMR研究的结果是有用的， 例如聚合物和催化剂。 化学共享仪器计划（Chemistry Shared Instruments Program） 将帮助麻省理工学院的化学系收购两家 高场多核NMR。 300和500 MHz NMR 光谱仪将用于多核研究 在以下化学领域的研究： 1. 酶机制 2. 蛋白质构象 3. 生物无机化学 4. 多肽和蛋白质的合成 5. 催化剂的合成方法与分子设计 光谱仪将主要用于2D NMR， 多核NMR光谱学。