CRB: Conservation Genetics and Inbreeding Depression

CRB：保护遗传学和近交衰退

• 批准号: 8923007
• 负责人: Philip Hedrick
• 金额: $ 8.7万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-01 至 1992-07-01
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8923007&HistoricalAwards=false
• 关键词: CRB; Conservation; Genetics; Inbreeding; Depression

The conservation of endangered species often hinges on the avoidance of inbreeding depression or the retention of genetic variation. Therefore, it is of fundamental importance for conservation biology to understand and characterize inbreeding depression. In the proposed research, inbreeding depression in Drosophila melanogaster as a model for endangered species in which such experimentation would not be possible. The influence of inbreeding on all components of fitness will be examined. In addition, the effect of inbreeding in the normal laboratory environment and two stress environments will be examined to obtain a more realistic view of the impact of inbreeding on endangered species. In a second component of the study a computer simulation program will be developed to analyze pedigree populations. Both genetic linkage and natural selection will be incorporated. As a result, the effect of different rates of inbreeding on inbreeding depression and the conditions for purging a population of lethal alleles will be determined. Furthermore, this technique will be applied to known pedigrees of endangered species to determine the expected inbreeding depression.

濒危物种的保护通常取决于避免近交衰退或保留遗传变异。 因此，理解和表征近交衰退对于保护生物学至关重要。 在拟议的研究中，黑腹果蝇的近交衰退作为濒危物种的模型，在这种情况下进行此类实验是不可能的。 将检查近亲繁殖对健康所有组成部分的影响。 此外，还将检查近交在正常实验室环境和两种应激环境中的影响，以获得近交对濒危物种影响的更现实的看法。 在该研究的第二个部分中，将开发计算机模拟程序来分析谱系种群。 遗传连锁和自然选择都将被纳入其中。 因此，将确定不同近交率对近交抑制的影响以及清除致命等位基因群体的条件。 此外，该技术将应用于已知的濒危物种谱系，以确定预期的近交衰退。