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Development of a pre-clinical mouse model of Estrogen receptor alpha positive breast cancer to investigate the clinical efficacy of Selective Estrogen Receptor Modulators (SERMs)

Development of a pre-clinical mouse model of Estrogen receptor alpha positive breast cancer to investigate the clinical efficacy of Selective Estrogen Receptor Modulators (SERMs)
开发雌激素受体α阳性乳腺癌临床前小鼠模型,以研究选择性雌激素受体调节剂(SERM)的临床疗效
批准号:
341905
负责人:
Muller William J
金额:
$59.59万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-03-01 至 2022-03-01

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中文摘要
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英文摘要
Breast cancer remains a prevalent disease and major cause of morbidity in women. Amongst the most prevalent oncogene drivers in breast cancer is the Estrogen Receptor alpha (ERa), one of the major receptors for estrogens. Treatment of ERa positive breast
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会议论文
Identifying the molecular and environmental factors involved in promoting escape from breast cancer dormancy.
  • 批准号:
    488246
  • 项目类别:
    Operating Grants
  • 资助金额:
    $83.04万
  • 财政年份:
    2023
  • 负责人:
    Muller William J
  • 依托单位:
Chi3L1 (YKL-40) plays a multifaceted role in modulating tumor immune microenvironment during breast cancer progression.
  • 批准号:
    478513
  • 项目类别:
    Operating Grants
  • 资助金额:
    $93.07万
  • 财政年份:
    2023
  • 负责人:
    Muller William J
  • 依托单位:
Identifying the molecular and environmental factors involved in promoting escape from breast cancer dormancy.
  • 批准号:
    483129
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2023
  • 负责人:
    Muller William J
  • 依托单位:
Identification of Stat1 signaling pathway(s) involved in mediating tumor escape from immune surveillance.
  • 批准号:
    490747
  • 项目类别:
    Operating Grants
  • 资助金额:
    $4.55万
  • 财政年份:
    2023
  • 负责人:
    Muller William J
  • 依托单位:
海外基金