A Comprehensive Database of Nucleic Acid Structure

核酸结构综合数据库

• 批准号: 9012772
• 负责人: Helen Berman
• 金额: $ 71.32万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-15 至 1994-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9012772&HistoricalAwards=false
• 关键词: Comprehensive; Database; Nucleic; Acid; Structure

In order to understand the properties of nucleic acids and the mechanisms by which they are recognized by proteins, it is essential to understand the details of fine structure and couple the sequence and structure data. Our goal is to develop a database of nucleic acid structures and structural features so as to allow computer queries about structural characteristics, correlations of features among structures, and sequence-structure relationships. The achieve this goal, all of the available primary and calculated information about crystal structures of nucleic acids will be assembled into a relational database. The system that will be created will be portable and accessible to chemists and biologists in a large number of computer environments.

为了了解核酸的特性以及蛋白质识别核酸的机制，有必要了解精细结构的细节并将序列和结构数据结合起来。 我们的目标是开发一个核酸结构和结构特征的数据库，以便允许计算机查询结构特征、结构之间特征的相关性以及序列-结构关系。 为了实现这一目标，有关核酸晶体结构的所有可用的主要信息和计算信息将被组装到一个关系数据库中。 将创建的系统将是便携式的，可供化学家和生物学家在大量计算机环境中访问。