Nucleic Acid Structure Database

核酸结构数据库

• 批准号: 9510703
• 负责人: Helen Berman
• 金额: $ 186.14万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-15 至 2001-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9510703&HistoricalAwards=false
• 关键词: Nucleic; Acid; Structure; Database

9510703 Berman The award will support the continued development of the Nucleic Acid Database, a database of three-dimensional structures of oligonucleotides and nucleic acids. The goals of the project are to devise an easily accessible and user friendly resource that serves a broad, international group of users including crystallographers, theoreticians, modelers and other researchers interested in such structures. The goals of the project are to expand the scope of the database and to refine existing and develop new, user-friendly software that facilitate data entry and research on the database, rather than simply on individual entries. The expansion of scope will allow the database to accept direct entry by researchers of structural data on nucleic acids determined by x-ray crystallography. The database will continue to cooperate closely with the Protein DataBank at Brookhaven National Laboratory, and will now itself include structural information on proteins and protein-nucleic acid complexes derived from the Protein DataBank. In addition, the database will provide the first extensive test of the use of the mmCIF, a new, information-rich format for structural data on macromolecules that is expected to become a standard format for such data. ***

9510703伯曼该奖项将支持核酸数据库的继续发展，这是一个关于寡核苷酸和核酸的三维结构的数据库。该项目的目标是设计一种易于获取和用户友好的资源，为广泛的国际用户群体服务，包括结晶学家、理论家、模型师和对这种结构感兴趣的其他研究人员。该项目的目标是扩大数据库的范围，完善现有的、用户友好的新软件，以便利数据输入和对数据库的研究，而不是简单地输入单个条目。范围的扩大将使数据库能够接受研究人员直接输入由X射线结晶学确定的核酸结构数据。该数据库将继续与布鲁克海文国家实验室的蛋白质数据库密切合作，现在将包括蛋白质结构信息和蛋白质数据库衍生的蛋白质-核酸复合体。此外，该数据库将提供对MMCIF使用的第一次广泛测试，MMCIF是一种新的、信息丰富的大分子结构数据格式，预计将成为此类数据的标准格式。***