Nucleic Acid Structure Database

该奖项将支持核酸数据库的持续发展，这是一个关于寡核苷酸和核酸三维结构的数据库。该项目的目标是设计一个易于访问和用户友好的资源，服务于广泛的国际用户群，包括晶体学家，理论家，建模者和其他对这种结构感兴趣的研究人员。该项目的目标是扩大数据库的范围，改进现有的和发展新的用户友好的软件，以便利对数据库的数据输入和研究，而不是简单地对个别输入进行研究。范围的扩大将允许数据库接受研究人员直接输入由x射线晶体学测定的核酸结构数据。该数据库将继续与布鲁克海文国家实验室的蛋白质数据库密切合作，现在它本身将包括来自蛋白质数据库的蛋白质和蛋白质核酸复合物的结构信息。此外，该数据库将首次对mmCIF的使用进行广泛测试。mmCIF是一种新的、信息丰富的大分子结构数据格式，有望成为这类数据的标准格式。＊＊＊

9510703 Berman The award will support the continued development of the Nucleic Acid Database, a database of three-dimensional structures of oligonucleotides and nucleic acids. The goals of the project are to devise an easily accessible and user friendly resource that serves a broad, international group of users including crystallographers, theoreticians, modelers and other researchers interested in such structures. The goals of the project are to expand the scope of the database and to refine existing and develop new, user-friendly software that facilitate data entry and research on the database, rather than simply on individual entries. The expansion of scope will allow the database to accept direct entry by researchers of structural data on nucleic acids determined by x-ray crystallography. The database will continue to cooperate closely with the Protein DataBank at Brookhaven National Laboratory, and will now itself include structural information on proteins and protein-nucleic acid complexes derived from the Protein DataBank. In addition, the database will provide the first extensive test of the use of the mmCIF, a new, information-rich format for structural data on macromolecules that is expected to become a standard format for such data. ***