Macromolecular Structure Database (MSD)

蛋白质数据库（PDB）是关于生物大分子结构信息的唯一国际知识库和主要来源。因此，它是一个关键的研究资源和我们对生命系统的理解的核心组成部分。PDB服务于实验，结构和计算科学家的广泛社区，并作为各级教育工作者的资源。 PDB访问通过主要网站和FTP站点（www.pdb.org，ftp.pdb.org）或通过分布在世界各地的7个镜像站点提供。 结构生物学研究合作实验室（RCSB）管理PDB的目标是提供一个单一的、可搜索的、关于实验确定的大分子结构的准确且注释良好的数据档案。 目前正在使用区域公务员制度委员会开发的系统进行数据处理、归档、分发和查询，以及实物档案的维护。在本项目期间，计划开展的新活动如下。首先，正在通过提高处理的准确性和速度，确保整个档案尽可能统一和无差错，以及建立支持自动数据存放和交换功能的基础设施，改进数据处理。第二，通过实施一个新的系统来分发和存档所有PDB数据，并实现全面的结构数据分析，而无论地理位置、本地硬件或软件配置如何，数据存档、分发和查询能力正在得到改善。 最后，正在完成和维护一个全面的实物档案，以确保保存原始数据和与数据库交易有关的所有记录，包括说明其演变和维护情况的文件。 这一努力的结果将是蛋白质数据库对专家和非专家的效用和价值的显著提高。增加这项工作的广泛影响的机制包括：一系列讲习班和会议，积极参加科学会议，定期通讯，不断使用服务台，以增加专家和非专家研究界对PDB的访问和利用，以及使用焦点小组，以确保PDB数据的最大可用性。参与研究生和本科生课程的设计和实施以及结构化的研究机会正在被用来增加PDB对大学教育的影响。 参加教师培训研讨会和共同努力，推出教师发展计划提供了机会，使PDB资源的K/12环境。 通过巡回艺术展和频繁的新闻发布和信息节目，公众正在了解PDB的努力。 总的来说，这些努力将把PDB资源和活动的好处扩大到尽可能广泛的社区。

The Protein Data Bank (PDB) is the single international repository and primary source for information about the structure of biological macromolecules. As such, it is a key research resource and a central component to our understanding of living systems. The PDB serves a broad community of experimental, structural and computational scientists and serves as a resource for educators at all levels. PDB access is provided through primary web and ftp sites (www.pdb.org, ftp.pdb.org) or via 7 mirror sites distributed worldwide. The goal of the Research Collaboratory for Structural Biology (RCSB) in managing PDB is to provide a single, searchable archive of accurate and well-annotated data on experimentally determined macromolecular structure. Systems developed by RCSB are currently being used for data processing, archiving, distribution and query, as well as maintenance of the physical archive. In the current project period, new activities are planned as follows. First, data processing is being improved by increasing accuracy and speed of processing, ensuring that the entire archive is as uniform and error free as possible, and creating the infrastructure to support automated data deposition and exchange functions. Second, data archiving, distribution and query capabilities are being improved by implementing a new system for distribution and archiving of all PDB data, and enabling comprehensive structural data analyses regardless of geographic location, local hardware, or software configuration. Finally, completion and maintenance of a comprehensive physical archive is being undertaken to ensure the preservation of primary data and of all records associated with the transactions of the database including documents describing its evolution and maintenance. The result of this effort will be a significant improvement in the utility and value of the Protein Data Bank for both specialists and non-specialists alike. Mechanisms for increasing the broader impacts of this work include the following: a series of workshops and meeting sessions, active participation in scientific meetings, a regular newsletter, the on-going use of a help desk to increase the access and utility of PDB for the specialist and non-specialist research community, and use of focus groups to insure maximum usability of PDB data. Participation in graduate and undergraduate coursework design and implementation and in structured research opportunities is being used to increase the impact of PDB on university-level education. Participation in teacher training workshops and a collaborative effort to launch a teacher development program provide opportunities to bring PDB resources to the K/12 environment. The general public is being made aware of PDB efforts through a traveling art exhibit and through frequent news releases and informational programs. Collectively, these efforts will extend the benefits of PDB resources and activities to the broadest possible community.