Recording of Neural Activity From Sensory Cortex Using Silicon Based, Three Dimensional Electrode Arrays

使用硅基三维电极阵列记录感觉皮层的神经活动

• 批准号: 9016288
• 负责人: Richard Normann
• 金额: $ 3万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-15 至 1992-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9016288&HistoricalAwards=false
• 关键词: Recording; Neural; Activity; Sensory; Cortex

The volitional movement of ones limbs is commanded by electrical activity in the neurons of the motor cortex, the output part of the brain. In quadriplegia, the spinal cord is damaged, but the motor cortex is perfectly functional. This array of electrodes, implanted into motor cortex could be used to record the electrical activity of these neurons. The electrode array could then provide large numbers of signals which could control functional neuromuscular systems or external mechanical devices (wheelchairs, artificial limbs, etc.). A three dimensional electrode array could be used in this application. The array is constructed from monocrystaline silicon and contains 100 needle shaped electrodes which protrude from a 4mm x 4mm substrate. Each sharpened electrode is 1.5mm in length and is about 80 microns in diameter at its base. A modification of this silicon electrode array is used to conduct a set of experiments in cats 1) to demonstrate that such an array of electrodes is capable of recording cortical neural activity and 2) to optimize the electrical properties of the electrodes such that they can provide the greatest isolation of single unit or unit cluster neural activity.

肢体的意志运动是由电流控制的 运动皮层神经元的活动， 大脑 在四肢瘫痪中，脊髓受损，但 运动皮层功能完好 这个电极阵列， 植入运动皮层可以用来记录 这些神经元的电活动 电极阵列可以 然后提供大量的信号， 功能性神经肌肉系统或外部机械装置 （轮椅、假肢等）。 三维电极阵列可用于此 应用程序. 该阵列是由单晶 硅，并包含100个针状电极， 从4mm x 4mm基板。 每个尖锐电极为1.5mm in 长度和直径约80微米在其底部。 一 该硅电极阵列的修改被用于传导 一组猫的实验1）证明这样的阵列 能够记录皮层神经活动 以及2）优化电极的电性能 使得它们可以提供单个单元的最大隔离 或单位簇神经活动。