U.S.-Japan Joint Seminar: Selectivity in Synthetic and Bio-Organic Chemistry/June 1991/Tokyo, Japan

这笔奖金将用于资助6名美国科学家参加将于1991年6月2日至7日在日本东京举行的“合成和生物有机化学的选择性”联合研讨会。会议的重点将是不对称合成领域的动态科学进展，它涵盖了有机和无机化学的整个范围。1981年举行的关于这一问题的美日研讨会为两国的研究团体交流思想和信息提供了机会。然而，在过去的十年里，人们发现了大量的立体控制反应，这些反应曾经被认为是不可能通过非酶手段实现的。这些新工具的影响，加上新的酶和微生物技术，极大地重新定义了合成中绝对立体化学、区域化学和官能团选择性问题在学术和工业环境中的解决方式。现在有许多新的手性试剂和催化剂能够近乎完美地控制这些键的结构，从而建立新的立体化学关系。这些新技术的发展是基于最近对选择性和分子识别基本问题的深刻理解。该领域的巨大重要性体现在文献中主要贡献的高度国际性和跨学科性质上。研讨会的共同组织者是科罗拉多州立大学的Robert M. Williams教授和东京大学的Kenji Koga教授。主要讨论了新的不对称合成方法；酶、全细胞和无细胞生物反应器技术；天然产物的全合成；生物合成;催化抗体;以及反应机理。此外，还将为年轻的日本工业化学家举办海报活动。

This award will support the participation of six U.S. scientists in a joint seminar on "Selectivity in Synthetic and Bio-organic Chemistry," to be held in Tokyo, Japan, June 2-7, 1991. The focus of the meetings will be on the dynamic scientific advances in the area of asymmetric synthesis, which spans the entire spectrum of organic and inorganic chemistry. A U.S.-Japan seminar on this subject in 1981 served as an opportunity for research groups in the two countries to share ideas and information. During the last decade, however, there has been a virtual explosion in the discovery of reactions that deliver levels of stereocontrol once thought to be impossible to achieve via non-enzymatic means. The impact of these new tools, coupled with the new enzymatic and microbial technologies, has dramatically redefined the way absolute stereochemical, regiochemical and functional group selectivity issues in synthesis are being addressed in both academic and industrial environments. A multitude of new chiral reagents and catalysts now exist that are capable of exerting near-perfect control over those bond constructions where new stereochemical relationships are established. The development of these new technologies are based on recent, deep understanding of fundamental issues of selectivity and molecular recognition. The enormous importance of this area is manifested in the highly international and cross-disciplinary nature of the primary contributions in the literature. The co-organizers of the seminar are Professor Robert M. Williams of Colorado State Unversity and Professor Kenji Koga of the University of Tokyo. The main topics to be discussed are new asymmetric synthetic methodologies; enzymatic, whole cell and cell-free bio-reactor technologies; total synthesis of natural products; biosynthesis; catalytic antibodies; and reaction mechanisms. In addition, a poster session will be organized for young Japanese industrial chemists.