U.S.-Japan Joint Seminar: Selectivity in Synthetic and Bio-Organic Chemistry/June 1991/Tokyo, Japan

美日联合研讨会：合成和生物有机化学的选择性/1991 年 6 月/日本东京

• 批准号: 9016487
• 负责人: Robert Williams
• 金额: $ 2.01万
• 依托单位: Colorado State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-15 至 1992-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9016487&HistoricalAwards=false
• 关键词: U.S.; Japan; Joint; Seminar; Selectivity

This award will support the participation of six U.S. scientists in a joint seminar on "Selectivity in Synthetic and Bio-organic Chemistry," to be held in Tokyo, Japan, June 2-7, 1991. The focus of the meetings will be on the dynamic scientific advances in the area of asymmetric synthesis, which spans the entire spectrum of organic and inorganic chemistry. A U.S.-Japan seminar on this subject in 1981 served as an opportunity for research groups in the two countries to share ideas and information. During the last decade, however, there has been a virtual explosion in the discovery of reactions that deliver levels of stereocontrol once thought to be impossible to achieve via non-enzymatic means. The impact of these new tools, coupled with the new enzymatic and microbial technologies, has dramatically redefined the way absolute stereochemical, regiochemical and functional group selectivity issues in synthesis are being addressed in both academic and industrial environments. A multitude of new chiral reagents and catalysts now exist that are capable of exerting near-perfect control over those bond constructions where new stereochemical relationships are established. The development of these new technologies are based on recent, deep understanding of fundamental issues of selectivity and molecular recognition. The enormous importance of this area is manifested in the highly international and cross-disciplinary nature of the primary contributions in the literature. The co-organizers of the seminar are Professor Robert M. Williams of Colorado State Unversity and Professor Kenji Koga of the University of Tokyo. The main topics to be discussed are new asymmetric synthetic methodologies; enzymatic, whole cell and cell-free bio-reactor technologies; total synthesis of natural products; biosynthesis; catalytic antibodies; and reaction mechanisms. In addition, a poster session will be organized for young Japanese industrial chemists.

该奖项将支持6名美国科学家参加将于1991年6月2日至7日在日本东京举行的“合成和生物有机化学中的选择性”联合研讨会。会议的重点将是不对称合成领域的动态科学进展，该领域横跨有机化学和无机化学的整个光谱。1981年，美日就这一主题举行了一次研讨会，为两国的研究小组提供了交流想法和信息的机会。然而，在过去的十年里，在提供立体控制水平的反应的发现方面出现了虚拟的爆炸性增长，这些反应曾经被认为不可能通过非酶方法实现。这些新工具的影响，加上新的酶和微生物技术，极大地重新定义了在学术和工业环境中解决合成中绝对立体化学、区域化学和官能团选择性问题的方式。现在存在许多新的手性试剂和催化剂，能够对建立新的立体化学关系的键结构施加近乎完美的控制。这些新技术的发展是基于对选择性和分子识别等基本问题的最新、深入的理解。这一领域的巨大重要性体现在文献的主要贡献具有高度的国际性和跨学科性质。研讨会的联合组织者是科罗拉多州立大学的罗伯特·M·威廉姆斯教授和东京大学的古贺健二教授。主要讨论不对称合成新方法；酶、全细胞和无细胞生物反应器技术；天然产物的全合成；生物合成；催化抗体；反应机理。此外，还将为日本年轻的工业化学家组织一次海报会议。