Informatics Center for Mouse Neurogenetics

IBN-0003982 NIH/NSF人脑项目PI：Robert W. WilliamsInformatics Center for Mouse Neurogenetics本项目的目的是开发和利用一套图像数据库、电动互联网显微镜和软件来研究小鼠CNS结构变异的遗传基础。资源是开放的研究社区通过一个集成的网络接口在nervenet.org。该项目的重点是提供协作研究环境，为定位数量性状基因座（QTL）。 QTL分析是一个新兴的领域，解决了由许多基因调控的复杂生物性状。 四个新的资源和技术将被开发：1）小鼠大脑图书馆，2）互联网显微镜系统，3）神经制图项目，和4）神经遗传学工具箱。 实现这四个项目的目标将促进成年哺乳动物神经系统结构分析的新时代，并将导致大量关于人脑发育和衰老的新研究。这项研究部分由国家科学基金会通过参与人脑项目提供资金，人脑项目是一个联邦机构间研究计划，作为“大脑十年”的一部分。

IBN-0003982NIH/NSF Human Brain ProjectPI: Robert W. WilliamsInformatics Center for Mouse NeurogeneticsThe purpose of this project is to develop and exploit a suite of image databases, motorized Internet microscopes, and software to study the genetic basis of structural variation of the mouse CNS. Resources are open to the research community through an integrated web interface at nervenet.org. The focus of this project is to provide collaborative research environments for mapping quantitative trait loci (QTLs). QTL analysis is a burgeoning field that tackles complex biological traits modulated by many genes. Four new resources and technologies will be developed: 1) the Mouse Brain Library, 2) the Internet Microscope System, 3) the NeuroCartographer Project, and 4) the Neurogenetics Tool Box. Achieving the aims of these four projects will catalyze a new era in the structural analysis of the adult mammalian nervous system and will lead to a large number of novel lines of research on the development and aging of the human brain.This research is funded in part by the National Science Foundation through its participation in the Human Brain Project, which is a Federal interagency research initiative, mandated by Congress as part of the "Decade of the Brain".