Exploration Related Synaptic Changes in Rat Dentate Gyrus

大鼠齿状回探索相关突触变化

• 批准号: 9021632
• 负责人: Edward Green
• 金额: $ 14.86万
• 依托单位: University of Miami
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-15 至 1994-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9021632&HistoricalAwards=false
• 关键词: Exploration; Related; Synaptic; Changes; Rat

Dr. Edward Green is studying the intricate electrophysiology of a brain structure, the hippocampus, which is known to be involved in learning and memory. His work should provide important information regarding the nature of the information processing which takes place in the dentate gyrus, a special region of the hippocampus, during exploratory behavior. Furthermore, this work is designed to evaluate functional alterations in the hippocampus associated with behavioral exploration. The proposed studies will utilize electrophysiological recordings of field potentials and single unit responses of granule cells in the dentate gyrus of freely moving rats. The specific goals of the work include: a) an evaluation of the interaction between the transient alterations in synaptic transmission related to behavioral state, and moderately persistent changes in synaptic efficacy that are associated with exploratory behavior; b) an assessment of the role of adrenal hormones in naturally occurring, synaptic efficacy changes in the dentate gyrus that accompany exploratory behavior; c) a determination of whether the locus coeruleus is necessary for producing environmentally-modulated alterations in granule cell excitability; d) an evaluation of whether naturally- occurring alterations in synaptic efficacy and electrically - induced long-term potentiation share a common synaptic mechanism; and e) a comparison of granule cell unit activity during specific behaviors in the home environment to unit activity during the same behaviors following exploration. Findings from these studies will provide us with detailed information about how a specific area of the brain processes information and retains that information for the purpose of memory storage.

爱德华·格林博士正在研究大脑结构海马体的复杂电生理学，海马体被认为与学习和记忆有关。他的工作应该提供关于在探索行为中发生在齿状回（海马体的一个特殊区域）的信息处理性质的重要信息。此外，这项工作旨在评估与行为探索相关的海马体功能改变。本研究将利用自由运动大鼠齿状回颗粒细胞的场电位和单单位反应的电生理记录。本研究的具体目标包括：a)评估与行为状态相关的突触传递的短暂改变与与探索性行为相关的突触效能的中度持续变化之间的相互作用；B)评估肾上腺激素在伴随探索行为的齿状回自然发生的突触效能变化中的作用；C)确定蓝斑位点对于产生环境调节的颗粒细胞兴奋性改变是否必要；D)评估自然发生的突触效能改变和电诱导的长期增强是否具有共同的突触机制；e)在家庭环境中特定行为期间的颗粒细胞单位活动与探索后相同行为期间的单位活动的比较。这些研究的发现将为我们提供有关大脑特定区域如何处理信息并保留信息以存储记忆的详细信息。