Vesicle Stabilization and Destabilization

囊泡稳定和不稳定

• 批准号: 9104028
• 负责人: David Jaeger
• 金额: $ 32.54万
• 依托单位: University of Wyoming
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-15 至 1995-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9104028&HistoricalAwards=false
• 关键词: Vesicle; Stabilization; Destabilization

With support from the Organic Dynamics Program, Dr. Jaeger will develop and evaluate strategies for stabilizing and destabilizing vesicle bilayer membranes. The resultant strategies can be applied in chemical reagent storage and release. Objectives of the proposed studies include: (i) synthesis and characterization of new cleavable surfactants, (ii) characterization of derived vesicles, (iii) determination of cleavage rates for surfactants in vesicle form, and (iv) studies of vesicle entrapment and release. %%% Vesicles (liposomes) are spherical or ellipsoidal single- and multicompartment closed bilayer structures formed by dispersion in water of double-chain synthetic and naturally occurring surfactants. The ability of vesicles to entrap hydrophilic and hydrophobic compounds in their aqueous compartments and inhydrocarbon bilayers, respectively, has led to intense interest in their use as devices for a number of applications, including chemical reagent storage and release. Enhancements of vesicular storage and release capabililties arise from bilayer membrane stabilization and destabilization, respectively. In this project, methods for chemically triggering the destruction of vesicles to release their contents will be explored.

在有机动力学项目的支持下，耶格博士将 制定和评估稳定和 使囊泡双层膜不稳定。所得 这些策略可以应用于化学试剂储存， release.拟议研究的目标包括： 新型可裂解表面活性剂的合成与表征， (ii)衍生囊泡的表征，（iii）测定 囊泡形式的表面活性剂的裂解速率，和（iv） 研究囊泡的捕获和释放。 %%% 囊泡（脂质体）是球形或椭圆形的单囊泡， 分散形成的多室封闭双层结构 双链合成和天然存在的水中 表面活性剂囊泡包埋亲水性和亲水性的能力是很重要的。 疏水化合物在它们的水性隔室中， 在碳氢化合物双层，分别，导致了强烈的 感兴趣的是将它们用作许多应用的装置， 包括化学试剂的储存和释放。量增加 囊泡的储存和释放能力来自双层 膜稳定化和去稳定化。在 这个项目，化学触发销毁的方法， 释放囊泡内容物的方法将被探索。