Vesicle Stabilization and Destabilization

在有机动力学项目的支持下，耶格博士将开发和评估稳定和破坏囊泡双层膜的策略。所得策略可应用于化学试剂的储存和释放。拟议研究的目标包括：(i)合成和表征新的可切割表面活性剂，（ii）表征衍生囊泡，（iii）确定囊泡形式的表面活性剂的切割速率，以及（iv）囊泡捕获和释放的研究。囊泡（脂质体）是双链合成和天然表面活性剂在水中分散形成的球形或椭球状单室和多室封闭双层结构。囊泡能够将亲水性和疏水性化合物分别捕获在其水室和碳氢化合物双分子层中，这引起了人们对它们作为许多应用设备的强烈兴趣，包括化学试剂的储存和释放。囊泡储存和释放能力的增强分别来自双层膜的稳定和不稳定。在这个项目中，将探索化学触发囊泡破坏以释放其内容物的方法。

With support from the Organic Dynamics Program, Dr. Jaeger will develop and evaluate strategies for stabilizing and destabilizing vesicle bilayer membranes. The resultant strategies can be applied in chemical reagent storage and release. Objectives of the proposed studies include: (i) synthesis and characterization of new cleavable surfactants, (ii) characterization of derived vesicles, (iii) determination of cleavage rates for surfactants in vesicle form, and (iv) studies of vesicle entrapment and release. %%% Vesicles (liposomes) are spherical or ellipsoidal single- and multicompartment closed bilayer structures formed by dispersion in water of double-chain synthetic and naturally occurring surfactants. The ability of vesicles to entrap hydrophilic and hydrophobic compounds in their aqueous compartments and inhydrocarbon bilayers, respectively, has led to intense interest in their use as devices for a number of applications, including chemical reagent storage and release. Enhancements of vesicular storage and release capabililties arise from bilayer membrane stabilization and destabilization, respectively. In this project, methods for chemically triggering the destruction of vesicles to release their contents will be explored.