Regioselectivity Control of Diels-Alder Reactions by Surfactant-Based Organized Media

基于表面活性剂的有序介质对狄尔斯-阿尔德反应的区域选择性控制

• 批准号: 9526188
• 负责人: David Jaeger
• 金额: $ 30.2万
• 依托单位: University of Wyoming
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-15 至 2000-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9526188&HistoricalAwards=false
• 关键词: Regioselectivity; Control; Diels; Alder; Reactions

With funding from the Organic Dynamics Program, Professor Jaeger at the University of Wyoming will investigate the concept that organized media in the form of surfactants can be used to control and increase the regioselectivity of Diels-Alder reactions. In this concept, the reagents will aggregate inside of a molecular box(surfactant) that will favor certain orientations which predetermines the reagent trajectories and thereby the products. Further, as a result of this predisposition of reagents, the energy necessary to facilitate the process in the succeeding steps will be lessened. Thus, the reactions can be conducted at lower temperatures and regioselectivity should increase. If successful, the results would have significant impact on the area of organic synthesis. Achievement of control over a commonly used organic reaction methodology would provide academic and industrial scientists a significant advantage. This research effort is designed to determine whether surfactants can be useful in controlling some aspects of the Diels-Alder reaction which is a common methodology in organic synthesis. To control this reaction so as to produce only one type of product would be a major achievement

在有机动力学项目的资助下， 怀俄明州大学将研究有组织的媒体 表面活性剂的形式可用于控制和增加 Diels-Alder反应的区域选择性。在这个概念中，试剂 将聚集在分子盒（表面活性剂）内， 预先确定试剂轨迹的某些方向， 因此产品。此外，由于这种倾向， 反应物，促进反应过程所需的能量， 后续步骤将减少。因此，可以进行反应， 在较低的温度和区域选择性应增加。如果 如果成功，其结果将对以下领域产生重大影响： 有机合成 实现对常用有机反应方法的控制 将为学术界和工业界的科学家提供一个显著的优势。 这项研究工作旨在确定表面活性剂是否可以 可用于控制Diels-Alder反应的某些方面， 有机合成中的常用方法。为了控制这种反应， 只生产一种产品将是一项重大成就