Regioselectivity Control of Diels-Alder Reactions by Surfactant-Based Organized Media

在有机动力学项目的资助下，怀俄明大学的Jaeger教授将研究表面活性剂形式的有组织介质可用于控制和提高Diels-Alder反应的区域选择性这一概念。在这个概念中，试剂将聚集在一个分子盒(表面活性剂)内，该分子盒将有利于预先确定试剂轨迹的特定方向，从而确定产品。此外，由于试剂的这种预置，在后续步骤中促进该过程所需的能量将会减少。因此，反应可以在较低的温度下进行，区域选择性应该会提高。如果成功，这一结果将对有机合成领域产生重大影响。实现对常用的有机反应方法学的控制将为学术和工业科学家提供显著的优势。这项研究旨在确定表面活性剂是否可用于控制Diels-Alder反应的某些方面，Diels-Alder反应是有机合成中常用的方法。控制这种反应，使其只产生一种产物，这将是一项重大成就。

With funding from the Organic Dynamics Program, Professor Jaeger at the University of Wyoming will investigate the concept that organized media in the form of surfactants can be used to control and increase the regioselectivity of Diels-Alder reactions. In this concept, the reagents will aggregate inside of a molecular box(surfactant) that will favor certain orientations which predetermines the reagent trajectories and thereby the products. Further, as a result of this predisposition of reagents, the energy necessary to facilitate the process in the succeeding steps will be lessened. Thus, the reactions can be conducted at lower temperatures and regioselectivity should increase. If successful, the results would have significant impact on the area of organic synthesis. Achievement of control over a commonly used organic reaction methodology would provide academic and industrial scientists a significant advantage. This research effort is designed to determine whether surfactants can be useful in controlling some aspects of the Diels-Alder reaction which is a common methodology in organic synthesis. To control this reaction so as to produce only one type of product would be a major achievement