Molecular Evolution of Holostean Pituitary Hormones

全骨垂体激素的分子进化

• 批准号: 9104707
• 负责人: Robert Dores
• 金额: $ 10.49万
• 依托单位: University of Denver
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-11-01 至 1995-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9104707&HistoricalAwards=false
• 关键词: Molecular; Evolution; Holostean; Pituitary; Hormones

The evolution of the Actinopterygii (ray finned fish) has proceeded in three stages. The first group were the Chondrostei. This group was succeeded by the Holostean fishes which were superceded by the Teleosts, the most diverse group of living vertebrates. The fossil record indicates that Holostean fish were the ancestors to the Teleosts. Only two genera of Holosteans have survived (Amia and Lepisosteus). Amia is a "living fossil." This proposal will focus on the biochemical characterization of several pituitary hormones found in Amia using state of the art techniques of protein analysis and genetic engineering. These hormones will be compared with those of more "advanced" fishes. Holosteans are commercially important and the study may provide insights into ways to better manage this fishery. //

放线鳍鱼的进化经历了三个阶段。第一组是软骨动物。这一类被全息鱼类取代，被硬骨鱼取代，硬骨鱼是现存脊椎动物中最多样化的一类。化石记录表明，全息鱼类是硬骨鱼的祖先。只有两个Holosteans属幸存下来(Amia和Lesssteus)。AMIA是一块“活化石”。这项建议将侧重于利用最先进的蛋白质分析和基因工程技术对在AMIA中发现的几种脑下垂体激素进行生化表征。这些激素将与更高级的鱼类的激素进行比较。Holosteans具有重要的商业价值，这项研究可能会为更好地管理这一渔业提供见解。//